Pineal Region Germinoma in the Seventh Decade of Life: A Case Report

Overview

Journal NMC Case Rep J

Specialty Neurology

Date 2019 Aug 17

PMID 31417835

Citations 1

Authors

Masakazu Sano

Shinya Jinguji

Junichi Yoshimura

Kouichirou Okamoto

Yukihiko Fujii

Affiliations

Soon will be listed here.

Abstract

Germ cell tumors typically occur in children and adolescents. We here report a rare case of pineal region germinoma in the seventh decade of life. A 62-year-old man presented with double vision. Computerized tomography and magnetic resonance imaging (MRI) identified a heterogeneously enhanced tumor with calcification in the pineal region with ventricular dilatation due to aqueduct stenosis. The tumor had not been observed at all on MRI obtained 2 years previously. The patient underwent endoscopic biopsy and third ventriculostomy for the obstructive hydrocephalus. The tumor was histopathologically diagnosed as a pure germinoma. The patient underwent radiomonotherapy, resulting in his complete remission, which was confirmed by a series of follow-up MRI studies and hematological examinations. Intracranial germinoma should be considered in the differential diagnosis of pineal region tumors regardless of age, even though the tumor was undetectable on the previous neuroimaging.

Citing Articles

Molecular Pathology and Targeted Therapies for Personalized Management of Central Nervous System Germinoma.

Ilcus C, Silaghi H, Georgescu C, Georgiu C, Ciurea A, Nicoara S J Pers Med. 2021; 11(7).

PMID: 34357128 PMC: 8306901. DOI: 10.3390/jpm11070661.

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