Diagnosis: Gastric Intestinal Metaplasia - What to Do Next?

Overview

Journal Curr Opin Gastroenterol

Specialty Gastroenterology

Date 2019 Aug 16

PMID 31415250

Citations 13

Authors

David Y Graham

Massimo Rugge

Robert M Genta

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: One of the most vexing problems for gastroenterologists is what actions to take after receiving a histological diagnosis of gastric intestinal metaplasia. We approach the problem by starting with suggesting a biopsy protocol that ensures obtaining the biopsies required for diagnosis, assessing the status of the gastric mucosa, and effective communication with the pathologist and patient.

Recent Findings: The rediscovery and integration of the long history of gastric damage and repair resulting in pseudopyloric metaplasia (called SPEM) into the thinking of investigators working with animal models of gastric cancer has resulted in improved ability to separate changes associated with benign repair from those associated with inflammation-associated gastric carcinogenesis.

Summary: Gastric intestinal metaplasia is a potential reversible product of injury and repair and not directly connected with carcinogenesis. Intestinal metaplasia is a biomarker for prior gastric injury and repair. The risk of gastric cancer is best assessed in relation to the severity, extent, and, most importantly, the cause of the atrophic changes.

Citing Articles

Unveiling Cancer-Related Metaplastic Cells in Both Helicobacter pylori Infection and Autoimmune Gastritis.

Hoft S, Brennan M, Carrero J, Jackson N, Pretorius C, Bigley T Gastroenterology. 2024; 168(1):53-67.

PMID: 39236896 PMC: 11663102. DOI: 10.1053/j.gastro.2024.08.032.

Modeling gastric intestinal metaplasia in 3D organoids using nitrosoguanidine.

Li Y, Chen J, Li T, Lin J, Zheng H, Johnson N J Mol Cell Biol. 2024; 16(7.

PMID: 39153963 PMC: 11744189. DOI: 10.1093/jmcb/mjae030.

Peripheral Blood Inflammatory Markers as A Reliable Predictor of Gastric Mucosal Metaplasia Change in the Middle-aged Population.

Lai C, Lee C, Yeh T, Chang M, Lin Y, Chen T J Cancer. 2024; 15(11):3313-3320.

PMID: 38817866 PMC: 11134446. DOI: 10.7150/jca.95159.

Investigating FGFR2 gene as a blood-based epigenetic biomarker in gastric cancer.

Aleyasin S, Moradi A, Abolhasani N, Abdollahi M Mol Biol Rep. 2024; 51(1):253.

PMID: 38302798 DOI: 10.1007/s11033-023-09082-0.

Gastric intestinal metaplasia: progress and remaining challenges.

Tong Q, Pang M, Hu X, Huang X, Sun J, Wang X J Gastroenterol. 2024; 59(4):285-301.

PMID: 38242996 DOI: 10.1007/s00535-023-02073-9.

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