Early Second Trimester Maternal Serum Steroid-Related Biomarkers Associated with Autism Spectrum Disorder

Overview

Journal J Autism Dev Disord

Publisher Springer

Date 2019 Aug 15

PMID 31410696

Citations 16

Authors

Deborah A Bilder

M Sean Esplin

Hilary Coon

Paul Burghardt

Erin A S Clark

Alison Fraser

Ken R Smith

Whitney Worsham

Katlin Chappelle

Thomas Rayner

Amanda V Bakian

Affiliations

Soon will be listed here.

Abstract

Epidemiologic studies link increased autism spectrum disorder (ASD) risk to obstetrical conditions associated with inflammation and steroid dysregulation, referred to as prenatal metabolic syndrome (PNMS). This pilot study measured steroid-related biomarkers in early second trimester maternal serum collected during the first and second trimester evaluation of risk study. ASD case and PNMS exposure status of index offspring were determined through linkage with autism registries and birth certificate records. ASD case (N = 53) and control (N = 19) groups were enriched for PNMS exposure. Higher estradiol and lower sex hormone binding globulin (SHBG) were significantly associated with increased ASD risk. Study findings provide preliminary evidence to link greater placental estradiol activity with ASD and support future investigations of the prenatal steroid environment in ASD.

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References

Moisiadis V, Matthews S . Glucocorticoids and fetal programming part 1: Outcomes. Nat Rev Endocrinol. 2014; 10(7):391-402. DOI: 10.1038/nrendo.2014.73. View

Ishimoto H, Jaffe R . Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit. Endocr Rev. 2010; 32(3):317-55. PMC: 3365797. DOI: 10.1210/er.2010-0001. View

Goebelsmann U, Jaffe R . Oestriol metabolism in pregnant women. Acta Endocrinol (Copenh). 1971; 66(4):679-93. DOI: 10.1530/acta.0.0660679. View

Murphy V, Smith R, Giles W, Clifton V . Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus. Endocr Rev. 2006; 27(2):141-69. DOI: 10.1210/er.2005-0011. View

Tordjman S, Anderson G, Kermarrec S, Bonnot O, Geoffray M, Brailly-Tabard S . Altered circadian patterns of salivary cortisol in low-functioning children and adolescents with autism. Psychoneuroendocrinology. 2014; 50:227-45. DOI: 10.1016/j.psyneuen.2014.08.010. View

Hisle-Gorman E, Susi A, Stokes T, Gorman G, Erdie-Lalena C, Nylund C . Prenatal, perinatal, and neonatal risk factors of autism spectrum disorder. Pediatr Res. 2018; 84(2):190-198. DOI: 10.1038/pr.2018.23. View

Jobe S, Tyler C, Magness R . Aberrant synthesis, metabolism, and plasma accumulation of circulating estrogens and estrogen metabolites in preeclampsia implications for vascular dysfunction. Hypertension. 2013; 61(2):480-7. PMC: 3674508. DOI: 10.1161/HYPERTENSIONAHA.111.201624. View

Resnik R, Killam A, Battaglia F, MAKOWSKI E, Meschia G . The stimulation of uterine blood flow by various estrogens. Endocrinology. 1974; 94(4):1192-6. DOI: 10.1210/endo-94-4-1192. View

Mesiano S, Jaffe R . Developmental and functional biology of the primate fetal adrenal cortex. Endocr Rev. 1997; 18(3):378-403. DOI: 10.1210/edrv.18.3.0304. View

10.

Kinnunen T, Luoto R, Gissler M, Hemminki E, Hilakivi-Clarke L . Pregnancy weight gain and breast cancer risk. BMC Womens Health. 2004; 4(1):7. PMC: 535935. DOI: 10.1186/1472-6874-4-7. View

11.

Baron-Cohen S, Auyeung B, Norgaard-Pedersen B, Hougaard D, Abdallah M, Melgaard L . Elevated fetal steroidogenic activity in autism. Mol Psychiatry. 2014; 20(3):369-76. PMC: 4184868. DOI: 10.1038/mp.2014.48. View

12.

Zinke K, Fries E, Kliegel M, Kirschbaum C, Dettenborn L . Children with high-functioning autism show a normal cortisol awakening response (CAR). Psychoneuroendocrinology. 2010; 35(10):1578-82. DOI: 10.1016/j.psyneuen.2010.03.009. View

13.

Abbott D, Bird I . Nonhuman primates as models for human adrenal androgen production: function and dysfunction. Rev Endocr Metab Disord. 2008; 10(1):33-42. PMC: 2653599. DOI: 10.1007/s11154-008-9099-8. View

14.

Howland M, Sandman C, Glynn L . Developmental origins of the human hypothalamic-pituitary-adrenal axis. Expert Rev Endocrinol Metab. 2018; 12(5):321-339. PMC: 6334849. DOI: 10.1080/17446651.2017.1356222. View

15.

Tulchinsky D, Korenman S . The plasma estradiol as an index of fetoplacental function. J Clin Invest. 1971; 50(7):1490-7. PMC: 292089. DOI: 10.1172/JCI106634. View

16.

Lawrence J, Contreras R, Chen W, Sacks D . Trends in the prevalence of preexisting diabetes and gestational diabetes mellitus among a racially/ethnically diverse population of pregnant women, 1999-2005. Diabetes Care. 2008; 31(5):899-904. DOI: 10.2337/dc07-2345. View

17.

Shin Y, Jeong J, Park M, Lee J, An S, Cho W . Regulation of steroid hormones in the placenta and serum of women with preeclampsia. Mol Med Rep. 2017; 17(2):2681-2688. DOI: 10.3892/mmr.2017.8165. View

18.

Petridou E, Katsouyanni K, Hsieh C, Antsaklis A, Trichopoulos D . Diet, pregnancy estrogens and their possible relevance to cancer risk in the offspring. Oncology. 1992; 49(2):127-32. DOI: 10.1159/000227025. View

19.

Magness R, Rosenfeld C . Local and systemic estradiol-17 beta: effects on uterine and systemic vasodilation. Am J Physiol. 1989; 256(4 Pt 1):E536-42. DOI: 10.1152/ajpendo.1989.256.4.E536. View

20.

Holl K, Lundin E, Kaasila M, Grankvist K, Afanasyeva Y, Hallmans G . Effect of long-term storage on hormone measurements in samples from pregnant women: the experience of the Finnish Maternity Cohort. Acta Oncol. 2007; 47(3):406-12. PMC: 2886582. DOI: 10.1080/02841860701592400. View