MiR-497-5p Inhibits Gastric Cancer Cell Proliferation and Growth Through Targeting PDK3

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2019 Aug 15

PMID 31409724

Citations 28

Authors

Lan Feng

Kai Cheng

Rongjia Zang

Qingdong Wang

Jianjie Wang

Affiliations

Soon will be listed here.

Abstract

MicroRNA plays an important role in gastric cancer (GC) development, while the function of miR-497-5p in this disease remains unknown. In the present study, we demonstrated miR-497-5p as a tumor suppressive microRNA in GC. miR-497-5p was down-regulated in GC tissues and its expression was associated with the disease stage. Inhibition of miR-497-5p promoted GC cell proliferation and growth. By contrast, miR-497-5p ectopic expression suppressed the proliferation and growth of GC cells. In addition, miR-497-5p inhibited DNA synthesis and enhanced apoptosis in GC cells. The cell cycle progression was suppressed by miR-497-5p. Mechanistically, miR-497-5p directly targeted and suppressed the expression of pyruvate dehydrogenase kinase 3 (PDK3), which is highly expressed in GC tissues. Over-expression of PDK3 promoted the proliferation of GC cells. Our study revealed that miR-497-5p inhibited GC cell proliferation and growth via targeting PDK3.

Citing Articles

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