Gender Differences in the Provision of Key Post-arrest Interventions for Out-of-hospital Cardiac Arrest (OHCA) Patients-protocol for a Systematic Review

Overview

Journal Syst Rev

Publisher Biomed Central

Date 2019 Aug 15

PMID 31409393

Citations 1

Authors

Morgan Slater

Victoria M Sparrow-Downes

Precilla Veigas

Joanna M Bielecki

Valeria E Rac

Affiliations

Soon will be listed here.

Abstract

Background: Evidence shows that the implementation of optimal post-arrest care significantly increases survival and functional outcomes among patients who experience an out-of-hospital cardiac arrest (OHCA). However, differences in OHCA survival have been reported between men and women, suggesting underlying differences in post-arrest care. This systematic review will evaluate gender differences in the provision of key post-arrest interventions.

Methods: Eligible studies will be identified through systematic searches of relevant databases. Randomized controlled trials and observational studies of adult patients will be eligible for inclusion if they report gender-specific data on the provision of one or more guideline-based post-arrest interventions in OHCA patients who survived to hospital admission. Two independent reviewers will perform both the title and abstract and full-text screening along with data abstraction for the selected studies. Study quality will be assessed using a modified Cochrane Risk of Bias tool for RCTs or the ROBINS-I tool for observational studies. The strength of evidence for each included study will be assessed using a modified Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) system.

Discussion: To our knowledge, this systematic review will be the first to address the association between patient gender and the provision of post-arrest care. The findings from this systematic review will provide valuable insight to gender disparities in the provision of post-arrest care. This systematic review was designed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. This protocol observes the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) statement.

Systematic Review Registration: PROSPERO CRD42012003096.

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References

Martinell L, Larsson M, Bang A, Karlsson T, Lindqvist J, Thoren A . Survival in out-of-hospital cardiac arrest before and after use of advanced postresuscitation care: a survey focusing on incidence, patient characteristics, survival, and estimated cerebral function after postresuscitation care. Am J Emerg Med. 2010; 28(5):543-51. DOI: 10.1016/j.ajem.2009.01.042. View

Safdar B, Stolz U, Stiell I, Cone D, Bobrow B, deBoehr M . Differential survival for men and women from out-of-hospital cardiac arrest varies by age: results from the OPALS study. Acad Emerg Med. 2014; 21(12):1503-11. DOI: 10.1111/acem.12540. View

Hollenbeak C, Weisman C, Rossi M, Ettinger S . Gender disparities in percutaneous coronary interventions for acute myocardial infarction in Pennsylvania. Med Care. 2005; 44(1):24-30. DOI: 10.1097/01.mlr.0000188915.66942.69. View

Mozaffarian D, Benjamin E, Go A, Arnett D, Blaha M, Cushman M . Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation. 2014; 131(4):e29-322. DOI: 10.1161/CIR.0000000000000152. View

Srichaiveth B, Ruengsakulrach P, Visudharom K, Sanguanwong S, Tangsubutr W, Insamian P . Impact of gender on treatment and clinical outcomes in acute ST elevation myocardial infarction patients in Thailand. J Med Assoc Thai. 2008; 90 Suppl 1:65-73. View

Wong M, Morrison L, Qiu F, Austin P, Cheskes S, Dorian P . Trends in short- and long-term survival among out-of-hospital cardiac arrest patients alive at hospital arrival. Circulation. 2014; 130(21):1883-90. DOI: 10.1161/CIRCULATIONAHA.114.010633. View

Mosca L, Linfante A, Benjamin E, Berra K, Hayes S, Walsh B . National study of physician awareness and adherence to cardiovascular disease prevention guidelines. Circulation. 2005; 111(4):499-510. DOI: 10.1161/01.CIR.0000154568.43333.82. View

Neumar R, Nolan J, Adrie C, Aibiki M, Berg R, Bottiger B . Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on.... Circulation. 2008; 118(23):2452-83. DOI: 10.1161/CIRCULATIONAHA.108.190652. View

Morrison L, Schmicker R, Weisfeldt M, Bigham B, Berg R, Topjian A . Effect of gender on outcome of out of hospital cardiac arrest in the Resuscitation Outcomes Consortium. Resuscitation. 2015; 100:76-81. PMC: 4761304. DOI: 10.1016/j.resuscitation.2015.12.002. View

10.

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009; 339:b2700. PMC: 2714672. DOI: 10.1136/bmj.b2700. View

11.

Pell J, Sirel J, Marsden A, Cobbe S . Sex differences in outcome following community-based cardiopulmonary arrest. Eur Heart J. 2000; 21(3):239-44. DOI: 10.1053/euhj.1999.1629. View

12.

Kim C, Fahrenbruch C, Cobb L, Eisenberg M . Out-of-hospital cardiac arrest in men and women. Circulation. 2001; 104(22):2699-703. DOI: 10.1161/hc4701.099784. View

13.

Perers E, Abrahamsson P, Bang A, Engdahl J, Lindqvist J, Karlson B . There is a difference in characteristics and outcome between women and men who suffer out of hospital cardiac arrest. Resuscitation. 1999; 40(3):133-40. DOI: 10.1016/s0300-9572(99)00022-2. View

14.

Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M . Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015; 350:g7647. DOI: 10.1136/bmj.g7647. View

15.

Bougouin W, Mustafic H, Marijon E, Murad M, Dumas F, Barbouttis A . Gender and survival after sudden cardiac arrest: A systematic review and meta-analysis. Resuscitation. 2015; 94:55-60. DOI: 10.1016/j.resuscitation.2015.06.018. View

16.

Lloyd-Jones D, Adams R, Brown T, Carnethon M, Dai S, de Simone G . Executive summary: heart disease and stroke statistics--2010 update: a report from the American Heart Association. Circulation. 2010; 121(7):948-54. DOI: 10.1161/CIRCULATIONAHA.109.192666. View

17.

Nolan J, Soar J, Eikeland H . The chain of survival. Resuscitation. 2006; 71(3):270-1. DOI: 10.1016/j.resuscitation.2006.09.001. View

18.

Maynard C, Litwin P, Martin J, Weaver W . Gender differences in the treatment and outcome of acute myocardial infarction. Results from the Myocardial Infarction Triage and Intervention Registry. Arch Intern Med. 1992; 152(5):972-6. View

19.

Cline S, von der Lohe E, Newman M, Groh W . Factors associated with poor survival in women experiencing cardiac arrest in a rural setting. Heart Rhythm. 2005; 2(5):492-6. DOI: 10.1016/j.hrthm.2005.01.018. View

20.

Sterne J, Hernan M, Reeves B, Savovic J, Berkman N, Viswanathan M . ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016; 355:i4919. PMC: 5062054. DOI: 10.1136/bmj.i4919. View