Co-infection of VvMDV with Multiple Subgroups of Avian Leukosis Viruses in Indigenous Chicken Flocks in China

Overview

Journal BMC Vet Res

Publisher Biomed Central

Specialty Veterinary Medicine

Date 2019 Aug 15

PMID 31409367

Citations 13

Authors

Tuofan Li

Jing Xie

Guangcheng Liang

Dan Ren

Shu Sun

Lu Lv

Quan Xie

Hongxia Shao

Wei Gao

Aijian Qin

Jianqiang Ye

Affiliations

Soon will be listed here.

Abstract

Background: In China, although the ALV eradication program and the MD vaccination strategy greatly reduce the disease burdens caused by the infection of ALV and MDV, the frequent emergence of novel ALV-K or vvMDV in the vaccinated chicken flock challenges the current control strategies for both diseases.

Results: In Guangdong Province, an indigenous chicken flock was infected with neoplastic disease. Hematoxylin-eosin staining of the tissues showed the typical characteristics of MDV and classical ALV infection. The PCR and sequencing data demonstrated that the identified MDV was clustered into a very virulent MDV strain endemic in domestic chickens in China. Moreover, subgroups ALV-A and ALV-K were efficiently recovered from two samples. The full genome sequence revealed that the ALV-K isolate was phylogenetically close to the ALV TW3593 isolate from Taiwan Province.

Conclusions: A co-infection of vvMDV with multiple ALV subgroups emerged in a chicken flock with neoplastic disease in Guangdong Province. The co-infection with different subgroups of ALV with vvMDV in one chicken flock poses the risk for the emergence of novel ALVs and heavily burdens the control strategy for MDV.

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