Mechanism of Fibrosis Induced by Spp

Overview

Journal Diseases

Date 2019 Aug 15

PMID 31409055

Citations 9

Authors

Fuqiu Niu

Shigui Chong

Mingqun Qin

Shenmei Li

Riming Wei

Yumin Zhao

Affiliations

Soon will be listed here.

Abstract

Infection with spp. causes fibrosis in various vital organs, including the liver and lungs. Hepatic fibrosis is a pathological feature of infection that destroys normal liver tissue, leading to jaundice, cholecystitis, portal hypertension, etc. Severe infections lead to liver failure and hepatic encephalopathy. The formation of peripheral fiberboards around the metacestode is a major reason as to why antiparasitic drugs fail to be effectively transported to the lesion site. Studies on the mechanism of hepatic fibrosis caused by are important for treatment in patients. Recent studies have focused on miRNA and TGF-β. More recent findings have focused on the generation of collagen fibers around the metacestode. In this review paper we focus on the mechanism by which the Echinococcus parasite induces fibrosis in liver and some other organs in intermediate hosts-animals as well as human beings.

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