A Comprehensive Review on the Chemical Constituents and Functional Uses of Walnut ( Spp.) Husk

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 Aug 15

PMID 31409014

Citations 37

Authors

Ali Jahanban-Esfahlan

Alireza Ostadrahimi

Mahnaz Tabibiazar

Ryszard Amarowicz

Affiliations

Soon will be listed here.

Abstract

The walnut (Juglans spp.) is an appreciated nut that belongs to the Juglandaceae family. The fruit includes four main parts: the kernel, the skin, the shell, and the green husk. It is widely cultivated due to its edible kernel. In walnut production centers, high amounts of the husk as an agro-forest waste product are produced and discarded away. Recently, it has been demonstrated that the walnut green husk could be valued as a source of different natural bioactive compounds with excellent antioxidant and antimicrobial properties. Regarding this respect, in this contribution, the current scientific knowledge on the antioxidant and antiradical activities, various identified and isolated individual chemical constituents, as well as the functional applications of the walnut husk with more emphasis on the Persian walnut (Juglans regia L.) are reviewed.

Citing Articles

Antioxidant and anti-inflammatory function of walnut green husk aqueous extract (WNGH-AE) on human hepatocellular carcinoma cells (HepG2) treated with t-BHP.

Li Z, Gao Y, Zhao C, An R, Wu Y, Huang Z PLoS One. 2025; 20(1):e0318005.

PMID: 39869626 PMC: 11771903. DOI: 10.1371/journal.pone.0318005.

Behavioral, Physiological, and Molecular Mechanisms Underlying the Adaptation of to the Fruits of a Marginal Host: Walnut ().

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Physicochemical and Functional Properties of Black Walnut and Sycamore Syrups.

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digestive properties and the bioactive effect of walnut green husk on human gut microbiota.

Zhao X, Ying J, Wang Z, Wang Y, Li Z, Gu T Front Microbiol. 2024; 15:1392774.

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Regulation of Intestinal Inflammation by Walnut-Derived Bioactive Compounds.

Dai K, Agarwal N, Rodriguez-Palacios A, Basson A Nutrients. 2024; 16(16).

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References

Montava-Jorda S, Quiles-Carrillo L, Richart N, Torres-Giner S, Montanes N . Enhanced Interfacial Adhesion of Polylactide/Poly(ε-caprolactone)/Walnut Shell Flour Composites by Reactive Extrusion with Maleinized Linseed Oil. Polymers (Basel). 2019; 11(5). PMC: 6572400. DOI: 10.3390/polym11050758. View

Xu H, Yu X, Qu S, Qu X, Jiang Y, Sui D . Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen species-dependent mechanism. Food Chem Toxicol. 2012; 50(3-4):590-6. DOI: 10.1016/j.fct.2012.01.002. View

Zhou Y, Yang B, Jiang Y, Liu Z, Liu Y, Wang X . Studies on Cytotoxic Activity against HepG-2 Cells of Naphthoquinones from Green Walnut Husks of Juglans mandshurica Maxim. Molecules. 2015; 20(9):15572-88. PMC: 6331885. DOI: 10.3390/molecules200915572. View

Srinivasan A, Viraraghavan T . Removal of oil by walnut shell media. Bioresour Technol. 2008; 99(17):8217-20. DOI: 10.1016/j.biortech.2008.03.072. View

Nagel J, Brinkoetter M, Magkos F, Liu X, Chamberland J, Shah S . Dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis. Nutrition. 2011; 28(1):67-75. PMC: 3237820. DOI: 10.1016/j.nut.2011.03.004. View

Liu Z . Chemical methods to evaluate antioxidant ability. Chem Rev. 2010; 110(10):5675-91. DOI: 10.1021/cr900302x. View

Ji Y, Qu Z, Zou X . Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway. Exp Toxicol Pathol. 2009; 63(1-2):69-78. DOI: 10.1016/j.etp.2009.09.010. View

Tapsell L, Gillen L, Patch C, Batterham M, Owen A, Bare M . Including walnuts in a low-fat/modified-fat diet improves HDL cholesterol-to-total cholesterol ratios in patients with type 2 diabetes. Diabetes Care. 2004; 27(12):2777-83. DOI: 10.2337/diacare.27.12.2777. View

Wang X, Li Z, Tao S . Removal of chromium (VI) from aqueous solution using walnut hull. J Environ Manage. 2008; 90(2):721-9. DOI: 10.1016/j.jenvman.2008.01.011. View

10.

Kris-Etherton P, Hu F, Ros E, Sabate J . The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms. J Nutr. 2008; 138(9):1746S-1751S. DOI: 10.1093/jn/138.9.1746S. View

11.

Pereira J, Oliveira I, Sousa A, Valentao P, Andrade P, Ferreira I . Walnut (Juglans regia L.) leaves: phenolic compounds, antibacterial activity and antioxidant potential of different cultivars. Food Chem Toxicol. 2007; 45(11):2287-95. DOI: 10.1016/j.fct.2007.06.004. View

12.

Davis L, Stonehouse W, Loots D, Mukuddem-Petersen J, van der Westhuizen F, Hanekom S . The effects of high walnut and cashew nut diets on the antioxidant status of subjects with metabolic syndrome. Eur J Nutr. 2007; 46(3):155-64. DOI: 10.1007/s00394-007-0647-x. View

13.

Martinez M, Labuckas D, Lamarque A, Maestri D . Walnut (Juglans regia L.): genetic resources, chemistry, by-products. J Sci Food Agric. 2010; 90(12):1959-67. DOI: 10.1002/jsfa.4059. View

14.

Oliveira I, Sousa A, Ferreira I, Bento A, Estevinho L, Pereira J . Total phenols, antioxidant potential and antimicrobial activity of walnut (Juglans regia L.) green husks. Food Chem Toxicol. 2008; 46(7):2326-31. DOI: 10.1016/j.fct.2008.03.017. View

15.

Zhou Y, Yang B, Liu Z, Jiang Y, Liu Y, Fu L . Cytotoxicity of Triterpenes from Green Walnut Husks of Juglans mandshurica Maxim in HepG-2 Cancer Cells. Molecules. 2015; 20(10):19252-62. PMC: 6331897. DOI: 10.3390/molecules201019252. View

16.

Kim S, Park K, Gu M . Toxicity of hexavalent chromium to Daphnia magna: influence of reduction reaction by ferrous iron. J Hazard Mater. 2002; 93(2):155-64. DOI: 10.1016/s0304-3894(02)00057-2. View

17.

Srinivasan A, Viraraghavan T . Oil removal from water using biomaterials. Bioresour Technol. 2010; 101(17):6594-600. DOI: 10.1016/j.biortech.2010.03.079. View

18.

Anderson K, Teuber S, Gobeille A, Cremin P, Waterhouse A, Steinberg F . Walnut polyphenolics inhibit in vitro human plasma and LDL oxidation. J Nutr. 2001; 131(11):2837-42. DOI: 10.1093/jn/131.11.2837. View

19.

Ardestaniyan M, Mostafapour Kandelous H, Saeidnia S, Gohari A, Amanzadeh A, Sanati H . Anti-proliferative and apoptotic activities of constituents of chloroform extract of Juglans regia leaves. Cell Prolif. 2014; 47(2):172-9. PMC: 6496928. DOI: 10.1111/cpr.12090. View

20.

Pitschmann A, Zehl M, Atanasov A, Dirsch V, Heiss E, Glasl S . Walnut leaf extract inhibits PTP1B and enhances glucose-uptake in vitro. J Ethnopharmacol. 2014; 152(3):599-602. DOI: 10.1016/j.jep.2014.02.017. View