Mortality and Trends in Stroke Patients with Seizures: A Contemporary Nationwide Analysis

Objective: Seizures are frequent among stroke patients. The goal of this study was to provide updated trends in seizures prevalence and mortality among hospitalized stroke patients.

Methods: Data from the National Inpatient Sample was used to estimate trends in seizures prevalence among stroke patients as well as mortality by seizures status, between 2006 and 2014. We used a logistic regression model to examine the association between seizures and mortality, accounting for extraneous factors.

Results: Overall 372,957 patients (6%) stroke patients had a secondary diagnosis of seizures. We found 29% higher odds of in-hospital death among stroke patients with a secondary diagnosis of seizures. The prevalence of seizures was more than two times higher among patients with hemorrhagic stroke (11.4%) compared to those with ischemic strokes (4.8%). The prevalence of seizures among stroke patients was 6.6% and 6.2% for all strokes, 12.6% and 12% for hemorrhagic strokes, and 5.3% and 5% for ischemic strokes respectively in 2006 and 2014. Although there was a steady decline in both groups, mortality rate among hospitalized stroke patients with seizures was consistently higher than in those without seizures for all strokes, ischemic strokes, and hemorrhagic strokes. Compared to patients with ischemic stroke and seizures, mortality rate was higher among patients with hemorrhagic stroke and seizures.

Significance: Seizures were present in nearly one out of 15 patients hospitalized for stroke and were more frequent among those with hemorrhagic stroke. There was a decline in mortality among stroke patients during the study period, which remained significantly higher in patients with seizures than in patients without seizures, and in those with hemorrhagic stroke compared to those with ischemic stroke.