Twenty-year Survival of Gastric Cancer with Peritoneal Metastases Using Long-term Normothermic Intraperitoneal 5-fluorouracil and Systemic Mitomycin C: A Case Report

Overview

Journal Int J Surg Case Rep

Specialty General Surgery

Date 2019 Aug 11

PMID 31399397

Citations 1

Authors

Paul H Sugarbaker

Affiliations

Soon will be listed here.

Abstract

Background: Primary gastric cancer that presents with peritoneal metastases has few options for successful treatment.

Methods: A simplified treatment plan started with total gastrectomy and hyperthermic intraperitoneal chemotherapy. After placement of an intraperitoneal port combined intraperitoneal and systemic chemotherapy was given for six months.

Results: The treatments were tolerated well and associated with an acceptable quality of life and no adverse events. The patient is a 20-year survivor of her disease.

Conclusions: Gastric cancer with peritoneal metastases was successfully treated with a combination of gastrectomy plus intraperitoneal and systemic chemotherapy. Further studies using this simplified approach may be indicated.

Citing Articles

lncRNA HIT000218960 enhances resistance to 5-fluorouracil by promoting HMGA2 and activating the AKT/mTOR/P70S6K pathway in gastric cancer cells.

Bai L, Dong K, Tong D, Shi X, Wei S, Cai Y Exp Ther Med. 2022; 24(2):527.

PMID: 35837027 PMC: 9257784. DOI: 10.3892/etm.2022.11454.

References

Sadeghi B, Arvieux C, Glehen O, Beaujard A, Rivoire M, Baulieux J . Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study. Cancer. 2000; 88(2):358-63. DOI: 10.1002/(sici)1097-0142(20000115)88:2<358::aid-cncr16>3.0.co;2-o. View

Sugarbaker P, Yonemura Y . Clinical pathway for the management of resectable gastric cancer with peritoneal seeding: best palliation with a ray of hope for cure. Oncology. 2000; 58(2):96-107. DOI: 10.1159/000012086. View

Yu W, Whang I, Chung H, AVERBACH A, Sugarbaker P . Indications for early postoperative intraperitoneal chemotherapy of advanced gastric cancer: results of a prospective randomized trial. World J Surg. 2001; 25(8):985-90. DOI: 10.1007/s00268-001-0067-7. View

Ajani J, Mansfield P, Janjan N, Morris J, Pisters P, Lynch P . Multi-institutional trial of preoperative chemoradiotherapy in patients with potentially resectable gastric carcinoma. J Clin Oncol. 2004; 22(14):2774-80. DOI: 10.1200/JCO.2004.01.015. View

Yan T, Black D, Sugarbaker P, Zhu J, Yonemura Y, Petrou G . A systematic review and meta-analysis of the randomized controlled trials on adjuvant intraperitoneal chemotherapy for resectable gastric cancer. Ann Surg Oncol. 2007; 14(10):2702-13. DOI: 10.1245/s10434-007-9487-4. View

Songun I, Putter H, Meershoek-Klein Kranenbarg E, Sasako M, van de Velde C . Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial. Lancet Oncol. 2010; 11(5):439-49. DOI: 10.1016/S1470-2045(10)70070-X. View

Yang X, Huang C, Suo T, Mei L, Yang G, Cheng F . Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer: final results of a phase III randomized clinical trial. Ann Surg Oncol. 2011; 18(6):1575-81. PMC: 3087875. DOI: 10.1245/s10434-011-1631-5. View

Sugarbaker P, Bijelic L . Adjuvant bidirectional chemotherapy using an intraperitoneal port. Gastroenterol Res Pract. 2012; 2012:752643. PMC: 3409540. DOI: 10.1155/2012/752643. View

Han D, Suh Y, Kong S, Lee H, Im S, Bang Y . Outcomes of surgery aiming at curative resection in good responder to induction chemotherapy for gastric cancer with distant metastases. J Surg Oncol. 2012; 107(5):511-6. DOI: 10.1002/jso.23284. View

10.

Canbay E, Mizumoto A, Ichinose M, Ishibashi H, Sako S, Hirano M . Outcome data of patients with peritoneal carcinomatosis from gastric origin treated by a strategy of bidirectional chemotherapy prior to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a single specialized center in Japan. Ann Surg Oncol. 2013; 21(4):1147-52. DOI: 10.1245/s10434-013-3443-2. View

11.

Nakajima T, Harashima S, Hirata M, Kajitani T . Prognostic and therapeutic values of peritoneal cytology in gastric cancer. Acta Cytol. 1978; 22(4):225-9. View

12.

Ikoma N, Chen H, Wang X, Blum M, Estrella J, Fournier K . Patterns of Initial Recurrence in Gastric Adenocarcinoma in the Era of Preoperative Therapy. Ann Surg Oncol. 2017; 24(9):2679-2687. DOI: 10.1245/s10434-017-5838-y. View

13.

Wagner A, Syn N, Moehler M, Grothe W, Yong W, Tai B . Chemotherapy for advanced gastric cancer. Cochrane Database Syst Rev. 2017; 8:CD004064. PMC: 6483552. DOI: 10.1002/14651858.CD004064.pub4. View

14.

Ishigami H, Fujiwara Y, Fukushima R, Nashimoto A, Yabusaki H, Imano M . Phase III Trial Comparing Intraperitoneal and Intravenous Paclitaxel Plus S-1 Versus Cisplatin Plus S-1 in Patients With Gastric Cancer With Peritoneal Metastasis: PHOENIX-GC Trial. J Clin Oncol. 2018; 36(19):1922-1929. DOI: 10.1200/JCO.2018.77.8613. View

15.

Agha R, Borrelli M, Farwana R, Koshy K, Fowler A, Orgill D . The SCARE 2018 statement: Updating consensus Surgical CAse REport (SCARE) guidelines. Int J Surg. 2018; 60:132-136. DOI: 10.1016/j.ijsu.2018.10.028. View

16.

Ikeguchi M, Oka A, Tsujitani S, Maeta M, Kaibara N . Relationship between area of serosal invasion and intraperitoneal free cancer cells in patients with gastric cancer. Anticancer Res. 1994; 14(5B):2131-4. View

17.

Rundback J, Gray R, Buck D, Dolmatch B, Haffner G, Horton K . Fluoroscopically guided peritoneal catheter placement for intraperitoneal chemotherapy. J Vasc Interv Radiol. 1994; 5(1):161-5. DOI: 10.1016/s1051-0443(94)71476-7. View

18.

Sugarbaker P, Averbach A, Jacquet P, Stephens A, Stuart O . A simplified approach to hyperthermic intraoperative intraperitoneal chemotherapy (HIIC) using a self retaining retractor. Cancer Treat Res. 1996; 82:415-21. DOI: 10.1007/978-1-4613-1247-5_26. View