Delayed Effects of Acute Reperfusion on Vascular Remodeling and Late-Phase Functional Recovery After Stroke

Overview

Journal Front Neurosci

Date 2019 Aug 10

PMID 31396042

Citations 6

Authors

Violeta Duran-Laforet

David Fernandez-Lopez

Alicia Garcia-Culebras

Juan Gonzalez-Hijon

Ana Moraga

Sara Palma-Tortosa

Isaac Garcia-Yebenes

Adrian Vega-Perez

Ignacio Lizasoain

Maria Angeles Moro

Affiliations

Soon will be listed here.

Abstract

Tissue perfusion is a necessary condition for vessel survival that can be compromised under ischemic conditions. Following stroke, delayed effects of early brain reperfusion on the vascular substrate necessary for remodeling, perfusion and maintenance of proper peri-lesional hemodynamics are unknown. Such aspects of ischemic injury progression may be critical for neurological recovery in stroke patients. This study aims to describe the impact of early, non-thrombolytic reperfusion on the vascular brain component and its potential contribution to tissue remodeling and long-term functional recovery beyond the acute phase after stroke in 3-month-old male C57bl/6 mice. Permanent (pMCAO) and transient (60 min, tMCAO) brain ischemia mouse models were used for characterizing the effect of early, non-thrombolytic reperfusion on the brain vasculature. Analysis of different vascular parameters (vessel density, proliferation, degeneration and perfusion) revealed that, while early middle cerebral artery recanalization was not sufficient to prevent sub-acute vascular degeneration within the ischemic brain regions, brain reperfusion promoted a secondary wave of vascular remodeling in the peri-lesional regions, which led to improved perfusion of the ischemic boundaries and late-phase neurological recovery. This study concluded that acute, non-thrombolytic artery recanalization following stroke favors late-phase vascular remodeling and improves peri-lesional perfusion, contributing to secondary functional recovery.

Citing Articles

The Pathophysiology of Collateral Circulation in Acute Ischemic Stroke.

Mangiardi M, Bonura A, Iaccarino G, Alessiani M, Bravi M, Crupi D Diagnostics (Basel). 2023; 13(14).

PMID: 37510169 PMC: 10378392. DOI: 10.3390/diagnostics13142425.

Importance of Delayed Reperfusions in Patients With Incomplete Thrombectomy.

Mujanovic A, Jungi N, Kurmann C, Dobrocky T, Meinel T, Almiri W Stroke. 2022; 53(11):3350-3358.

PMID: 36205143 PMC: 9586830. DOI: 10.1161/STROKEAHA.122.040063.

Three-dimensional visualization of cerebral blood vessels and neural changes in thick ischemic rat brain slices using tissue clearing.

Lee E, Hong S, Choi D, Gum S, Hwang M, Kim D Sci Rep. 2022; 12(1):15897.

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Behind the Wall-Compartment-Specific Neovascularisation during Post-Stroke Recovery in Mice.

Kolbinger A, Kestner R, Jencio L, Schaufele T, Vutukuri R, Pfeilschifter W Cells. 2022; 11(10).

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Influence of metabolic syndrome on post-stroke outcome, angiogenesis and vascular function in old rats determined by dynamic contrast enhanced MRI.

Pradillo J, Hernandez-Jimenez M, Fernandez-Valle M, Medina V, Ortuno J, Allan S J Cereb Blood Flow Metab. 2021; 41(7):1692-1706.

PMID: 34152893 PMC: 8221771. DOI: 10.1177/0271678X20976412.

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