Neutrophils As a Protagonist and Target in Chronic Rhinosinusitis

Overview

Journal Clin Exp Otorhinolaryngol

Date 2019 Aug 10

PMID 31394895

Citations 21

Authors

Hai Wang

Li Pan

Zheng Liu

Affiliations

Soon will be listed here.

Abstract

Neutrophils have traditionally been acknowledged as the first immune cells that are recruited to inflamed tissues during acute inflammation. By contrast, their importance in the context of chronic inflammation has been studied in less depth. Neutrophils can be recruited and are largely present in the nasal mucosa of patients with chronic rhinosinusitis (CRS) both in Asians and in Caucasians. Increased infiltration of neutrophils in patients with CRS has been linked to poor corticosteroid response and disease prognosis. Meanwhile, tissue neutrophils may possess specific phenotypic features distinguishing them from resting blood counterparts and are endowed with particular functions, such as cytokines and chemokines production, thus may contribute to the pathogenesis of CRS. This review aims to summarize our current understanding of the pathophysiologic mechanisms of CRS, with a focus on the roles of neutrophils. We discuss recruitment, function, and regulation of neutrophils in CRS and outline the potential therapeutic strategies targeting neutrophils.

Citing Articles

Sodium propionate decreases implant-induced foreign body response in mice.

do Carmo D, Lazari M, Dos Santos L, Costa P, Jesus I, Guatimosim S PLoS One. 2025; 20(2):e0316764.

PMID: 39970160 PMC: 11838875. DOI: 10.1371/journal.pone.0316764.

Biomarker Analysis in Upper Respiratory Tract Infections: Associations with Demographics and Clinical Outcomes.

Manole F, Manole A, Csep A, Davidescu L, Hozan C, Szilagy E Pediatr Rep. 2025; 17(1.

PMID: 39846516 PMC: 11755654. DOI: 10.3390/pediatric17010001.

Identification of hub genes associated with neutrophils in chronic rhinosinusitis with nasal polyps.

Guo Y, Sun Q, Yin J, Mou Y, Wang J, Wang Y Sci Rep. 2024; 14(1):19870.

PMID: 39191825 PMC: 11350000. DOI: 10.1038/s41598-024-70387-6.

Immune endotyping and gene expression profile of patients with chronic rhinosinusitis with nasal polyps in the aspirin-exacerbated respiratory disease (AERD) and the non-AERD subgroups.

Nazari J, Shahba F, Jafariaghdam N, Mohebbi S, Arshi S, Bemanian M Allergy Asthma Clin Immunol. 2024; 20(1):14.

PMID: 38360807 PMC: 10870654. DOI: 10.1186/s13223-024-00876-w.

Association between peripheral eosinophilia, JESREC score, and olfactory dysfunction in patients with chronic rhinosinusitis.

Zhang L, Li H, Wang T, Wang Z, Wu Y, Guo S Front Immunol. 2024; 15:1334656.

PMID: 38327522 PMC: 10847329. DOI: 10.3389/fimmu.2024.1334656.

References

Tauber S, Nau R . Immunomodulatory properties of antibiotics. Curr Mol Pharmacol. 2009; 1(1):68-79. View

Mahdavinia M, Engen P, LoSavio P, Naqib A, Khan R, Tobin M . The nasal microbiome in patients with chronic rhinosinusitis: Analyzing the effects of atopy and bacterial functional pathways in 111 patients. J Allergy Clin Immunol. 2018; 142(1):287-290.e4. PMC: 6890201. DOI: 10.1016/j.jaci.2018.01.033. View

Schleimer R . Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis. Annu Rev Pathol. 2016; 12:331-357. PMC: 5514544. DOI: 10.1146/annurev-pathol-052016-100401. View

Pothoven K, Norton J, Suh L, Carter R, Harris K, Biyasheva A . Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease. J Allergy Clin Immunol. 2016; 139(6):1966-1978.e9. PMC: 5529124. DOI: 10.1016/j.jaci.2016.10.039. View

Dale D, Boxer L, Liles W . The phagocytes: neutrophils and monocytes. Blood. 2008; 112(4):935-45. DOI: 10.1182/blood-2007-12-077917. View

Shi L, Song J, Xiong P, Cao P, Liao B, Ma J . Disease-specific T-helper cell polarizing function of lesional dendritic cells in different types of chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med. 2014; 190(6):628-38. DOI: 10.1164/rccm.201402-0234OC. View

Tsai Y, Hao S, Chen C, Wu W . Thromboxane A2 Regulates CXCL1 and CXCL8 Chemokine Expression in the Nasal Mucosa-Derived Fibroblasts of Chronic Rhinosinusitis Patients. PLoS One. 2016; 11(6):e0158438. PMC: 4924833. DOI: 10.1371/journal.pone.0158438. View

Shiozawa A, Miwa M, Ono N, Homma H, Hirotsu M, Ikeda K . Comparative analysis of cytokine release from epithelial cell cultures of the upper airway. Rhinology. 2015; 53(2):135-41. DOI: 10.4193/Rhino14.078. View

Ma J, Shi L, Deng Y, Wang H, Cao P, Long X . CD8(+) T cells with distinct cytokine-producing features and low cytotoxic activity in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps. Clin Exp Allergy. 2016; 46(9):1162-75. DOI: 10.1111/cea.12758. View

10.

Dalli J, Winkler J, Colas R, Arnardottir H, Cheng C, Chiang N . Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents. Chem Biol. 2013; 20(2):188-201. PMC: 3583372. DOI: 10.1016/j.chembiol.2012.11.010. View

11.

Kim D, Eun K, Kim M, Cho D, Han S, Han S . Comparison Between Signature Cytokines of Nasal Tissues in Subtypes of Chronic Rhinosinusitis. Allergy Asthma Immunol Res. 2019; 11(2):201-211. PMC: 6340796. DOI: 10.4168/aair.2019.11.2.201. View

12.

Tan B, Li Q, Suh L, Kato A, Conley D, Chandra R . Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2011; 128(6):1198-1206.e1. PMC: 3384688. DOI: 10.1016/j.jaci.2011.08.037. View

13.

Ley K, Hoffman H, Kubes P, Cassatella M, Zychlinsky A, Hedrick C . Neutrophils: New insights and open questions. Sci Immunol. 2018; 3(30). DOI: 10.1126/sciimmunol.aat4579. View

14.

Zhang Y, Gevaert E, Lou H, Wang X, Zhang L, Bachert C . Chronic rhinosinusitis in Asia. J Allergy Clin Immunol. 2017; 140(5):1230-1239. DOI: 10.1016/j.jaci.2017.09.009. View

15.

Shimizu S, Kouzaki H, Kato T, Tojima I, Shimizu T . HMGB1-TLR4 signaling contributes to the secretion of interleukin 6 and interleukin 8 by nasal epithelial cells. Am J Rhinol Allergy. 2016; 30(3):167-72. DOI: 10.2500/ajra.2016.30.4300. View

16.

Tomassen P, Vandeplas G, Van Zele T, Cardell L, Arebro J, Olze H . Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers. J Allergy Clin Immunol. 2016; 137(5):1449-1456.e4. DOI: 10.1016/j.jaci.2015.12.1324. View

17.

Wakashin H, Hirose K, Maezawa Y, Kagami S, Suto A, Watanabe N . IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. Am J Respir Crit Care Med. 2008; 178(10):1023-32. DOI: 10.1164/rccm.200801-086OC. View

18.

Wen W, Liu W, Zhang L, Bai J, Fan Y, Xia W . Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy. J Allergy Clin Immunol. 2012; 129(6):1522-8.e5. DOI: 10.1016/j.jaci.2012.01.079. View

19.

Soehnlein O, Steffens S, Hidalgo A, Weber C . Neutrophils as protagonists and targets in chronic inflammation. Nat Rev Immunol. 2017; 17(4):248-261. DOI: 10.1038/nri.2017.10. View

20.

Grunwell J, Stephenson S, Tirouvanziam R, Brown L, Brown M, Fitzpatrick A . Children with Neutrophil-Predominant Severe Asthma Have Proinflammatory Neutrophils With Enhanced Survival and Impaired Clearance. J Allergy Clin Immunol Pract. 2018; 7(2):516-525.e6. PMC: 6363859. DOI: 10.1016/j.jaip.2018.08.024. View