Serum Mac-2-binding Protein (M2BPGi) As a Marker of Chronological Liver Fibrosis in Biliary Atresia Patients with Cirrhosis

Overview

Journal Pediatr Surg Int

Specialties General Surgery
Pediatrics

Date 2019 Aug 9

PMID 31392502

Citations 8

Authors

Takehisa Ueno

Tasuku Kodama

Yuki Noguchi

Motonari Nomura

Ryuta Saka

Yuichi Takama

Yuko Tazuke

Kazuhiko Bessho

Hiroomi Okuyama

Affiliations

Soon will be listed here.

Abstract

Purpose: Biliary atresia (BA) is characterized by progressive liver fibrosis, but it is difficult to assess the progression after the patient develops cirrhosis. Mac-2-binding protein glycosylation isomer (M2BPGi) is a new marker for hepatic fibrosis. We examined the chronological changes in M2BPGi levels in BA patients with cirrhosis.

Methods: Patients with cirrhosis were selected from among pediatric BA patients who had their native livers. Serum M2BPGi levels and Child-Pugh classification were evaluated. A total of 11 pediatric BA patients with cirrhosis were recruited.

Results: Initial M2BPGi level after diagnosis of liver cirrhosis based on liver biopsy was on average 3.4, and the most recent M2BPGi level under observation was on average 4.3. The follow-up period from the initial M2BPGi measurement averaged 22.6 months. The ratio of the initial and most recent values (M2BPGi ratio) was on average 1.3 (0.5-2.4). Three cases with improved fibrosis (M2BPGi ratio < 1.0) remained in Child A, as did six cases (1.0 ≤ M2BPGi ratio < 2.0), but two cases with marked fibrosis progression (2.0 ≤ M2BPGi ratio) advanced to decompensated cirrhosis Child B.

Conclusion: M2BPGi is useful as a prognostic factor for BA patients with liver cirrhosis. In addition, fibrosis improved even after the development of cirrhosis.

Citing Articles

Impact of follow-up liver biopsy on long-term outcomes post-Kasai procedure in patients with biliary atresia.

Takase K, Ueno T, Matsumoto S, Uga N, Deguchi K, Nomura M Pediatr Surg Int. 2025; 41(1):88.

PMID: 40019581 PMC: 11870969. DOI: 10.1007/s00383-025-05979-y.

Biomarkers in biliary atresia - an elusive promise of predicting outcome.

Jagadisan B, Dhawan A Pediatr Res. 2025; .

PMID: 39774329 DOI: 10.1038/s41390-024-03772-6.

Progress in Biomarkers Related to Biliary Atresia.

Kong F, Dong R, Chen G, Sun S, Yang Y, Jiang J J Clin Transl Hepatol. 2024; 12(3):305-315.

PMID: 38426193 PMC: 10899875. DOI: 10.14218/JCTH.2023.00260.

New chemiluminescent enzyme immunoassay for quantitative measurement of Mac-2 binding protein glycosylation isomer in chronic liver disease.

Uojima H, Nakabayashi K, Yamasaki K, Sugiyama M, Ishii N, Shirabe K J Gastroenterol. 2023; 58(12):1252-1260.

PMID: 37812281 DOI: 10.1007/s00535-023-02043-1.

Early detection of liver fibrosis with serum Mac-2 binding protein glycosylation-modified isomer (M2BPGi) during follow-up intestinal failure patients without intestinal failure-associated liver disease (IFALD).

Ueno T, Takase K, Deguchi K, Masahata K, Nomura M, Watanabe M Pediatr Surg Int. 2022; 38(12):1807-1813.

PMID: 36125546 DOI: 10.1007/s00383-022-05240-w.

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