Targeting Biofilms: a Perspective on Preventing Dental Caries

Overview

Journal Medchemcomm

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2019 Aug 9

PMID 31391878

Citations 39

Authors

Amber M Scharnow

Amy E Solinski

William M Wuest

Affiliations

Soon will be listed here.

Abstract

The prevalence of biofilm diseases, and dental caries in particular, have encouraged extensive research on biofilms, including methods of preventing its formation. Numerous small molecules with specific anti-biofilm activity against this pathogen have been isolated and synthesized. Generally, these molecules can be characterized into three categories: sucrose-dependent anti-adhesion, sucrose-independent anti-adhesion and cellular signaling interference. This review aims to provide an overview of the current small molecule strategies used for targeting biofilms, and a perspective of the future for the field.

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References

Petersen P, Ogawa H . Prevention of dental caries through the use of fluoride--the WHO approach. Community Dent Health. 2016; 33(2):66-8. View

McGhie D, HUTCHISON J, Nye F, Ball A . Infective endocarditis caused by Streptococcus mutans. Br Heart J. 1977; 39(4):456-8. PMC: 483257. DOI: 10.1136/hrt.39.4.456. View

Banas J, Vickerman M . Glucan-binding proteins of the oral streptococci. Crit Rev Oral Biol Med. 2003; 14(2):89-99. DOI: 10.1177/154411130301400203. View

Khan R, Zakir M, Khanam Z, Shakil S, Khan A . Novel compound from Trachyspermum ammi (Ajowan caraway) seeds with antibiofilm and antiadherence activities against Streptococcus mutans: a potential chemotherapeutic agent against dental caries. J Appl Microbiol. 2010; 109(6):2151-9. DOI: 10.1111/j.1365-2672.2010.04847.x. View

Matsui R, Cvitkovitch D . Acid tolerance mechanisms utilized by Streptococcus mutans. Future Microbiol. 2010; 5(3):403-17. PMC: 2937171. DOI: 10.2217/fmb.09.129. View

Palombo E . Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral Diseases. Evid Based Complement Alternat Med. 2009; 2011:680354. PMC: 3145422. DOI: 10.1093/ecam/nep067. View

Kunze B, Reck M, Dotsch A, Lemme A, Schummer D, Irschik H . Damage of Streptococcus mutans biofilms by carolacton, a secondary metabolite from the myxobacterium Sorangium cellulosum. BMC Microbiol. 2010; 10:199. PMC: 2915981. DOI: 10.1186/1471-2180-10-199. View

Avila M, Ojcius D, Yilmaz O . The oral microbiota: living with a permanent guest. DNA Cell Biol. 2009; 28(8):405-11. PMC: 2768665. DOI: 10.1089/dna.2009.0874. View

Luo H, Liang D, Bao M, Sun R, Li Y, Li J . In silico identification of potential inhibitors targeting Streptococcus mutans sortase A. Int J Oral Sci. 2017; 9(1):53-62. PMC: 5379162. DOI: 10.1038/ijos.2016.58. View

10.

Milgrom P, Rothen M, Milgrom L . Developing Public Health Interventions with Xylitol for the US and US-Associated Territories and States. Suom Hammaslaakarilehti. 2007; 13(10-11):2-11. PMC: 1828118. View

11.

Long J, Cai Q, Steinwandel M, Hargreaves M, Bordenstein S, Blot W . Association of oral microbiome with type 2 diabetes risk. J Periodontal Res. 2017; 52(3):636-643. PMC: 5403709. DOI: 10.1111/jre.12432. View

12.

Listl S, Galloway J, Mossey P, Marcenes W . Global Economic Impact of Dental Diseases. J Dent Res. 2015; 94(10):1355-61. DOI: 10.1177/0022034515602879. View

13.

Walsh T, Oliveira-Neto J, Moore D . Chlorhexidine treatment for the prevention of dental caries in children and adolescents. Cochrane Database Syst Rev. 2015; (4):CD008457. PMC: 10726983. DOI: 10.1002/14651858.CD008457.pub2. View

14.

Flotra L, Gjermo P, Rolla G, WAERHAUG J . Side effects of chlorhexidine mouth washes. Scand J Dent Res. 1971; 79(2):119-25. DOI: 10.1111/j.1600-0722.1971.tb02001.x. View

15.

Aspiras M, Ellen R, Cvitkovitch D . ComX activity of Streptococcus mutans growing in biofilms. FEMS Microbiol Lett. 2004; 238(1):167-74. DOI: 10.1016/j.femsle.2004.07.032. View

16.

Adil M, Singh K, Verma P, Khan A . Eugenol-induced suppression of biofilm-forming genes in Streptococcus mutans: An approach to inhibit biofilms. J Glob Antimicrob Resist. 2016; 2(4):286-292. DOI: 10.1016/j.jgar.2014.05.006. View

17.

Sakaue Y, Domon H, Oda M, Takenaka S, Kubo M, Fukuyama Y . Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans. Microbiol Immunol. 2015; 60(1):10-6. DOI: 10.1111/1348-0421.12343. View

18.

Solinski A, Ochoa C, Lee Y, Paniak T, Kozlowski M, Wuest W . Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria. ACS Infect Dis. 2017; 4(2):118-122. PMC: 5869685. DOI: 10.1021/acsinfecdis.7b00178. View

19.

Sperandio B, Gautier C, Pons N, Ehrlich D, Renault P, Guedon E . Three paralogous LysR-type transcriptional regulators control sulfur amino acid supply in Streptococcus mutans. J Bacteriol. 2010; 192(13):3464-73. PMC: 2897675. DOI: 10.1128/JB.00119-10. View

20.

Koo H, Allan R, Howlin R, Stoodley P, Hall-Stoodley L . Targeting microbial biofilms: current and prospective therapeutic strategies. Nat Rev Microbiol. 2017; 15(12):740-755. PMC: 5685531. DOI: 10.1038/nrmicro.2017.99. View