Molecular Mechanisms of LncRNAs in Regulating Cancer Cell Radiosensitivity

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2019 Aug 9

PMID 31391206

Citations 25

Authors

Jiamin Zhu

Shusen Chen

Baixia Yang

Weidong Mao

Xi Yang

Jing Cai

Affiliations

Soon will be listed here.

Abstract

Radiotherapy is one of the main modalities of cancer treatment. However, tumor recurrence following radiotherapy occurs in many cancer patients. A key to solving this problem is the optimization of radiosensitivity. In recent years, long non-coding RNAs (lncRNAs), which affect the occurrence and development of tumors through a variety of mechanisms, have become a popular research topic. LncRNAs have been found to influence radiosensitivity by regulating various mechanisms, including DNA damage repair, cell cycle arrest, apoptosis, cancer stem cells regulation, epithelial-mesenchymal transition, and autophagy. LncRNAs are expected to become a potential therapeutic target for radiotherapy in the future. This article reviews recent advances in the role and mechanism of lncRNAs in tumor radiosensitivity.

Citing Articles

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