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Generation of Listeria Monocytogenes-specific T Cells Mediating Delayed Footpad Reaction and Protection in Neonatally Thymectomized Mice but Not in Nude Mice

Overview

Overview

Journal Med Microbiol Immunol

Specialty Allergy & Immunology

Date 1988 Jan 1

PMID 3138516

Citations 4

Authors

Authors

M Mitsuyama

Y Watanabe

M Sano

K Amako

K Nomoto

Affiliations

Affiliations

Soon will be listed here.

Abstract

Neonatally thymectomized (NTx) mice, sham-operated control mice and congenitally athymic nude mice were immunized with viable Listeria monocytogenes and their spleen cells examined for the capacity to transfer both delayed footpad reaction and protection against challenge at the site of local transfer. Cells from immune NTx mice conferred significant degrees of delayed footpad reaction and protection comparable to sham mice, while cells from immune nude (nu/nu) mice did not. This ability was completely eliminated by the treatment of cells with anti-Thy1, anti-Lyt1 or anti-L3T4 antibody plus complement but not with anti-Lyt2 antibody plus complement. These results indicated that NTx mice can normally mount the immunity to L. monocytogenes by generating Lyt1+2-, L3T4+ T cells. Immune competence of NTx mice and thymus dependency of various immune responses are discussed.

Citing Articles

Characterization of T-cell receptor gamma delta T cells appearing at the early phase of murine Listeria monocytogenes infection.

Matsuzaki G, Hiromatsu K, Yoshikai Y, Muramori K, Nomoto K Immunology. 1993; 78(1):22-7.

PMID: 8094708 PMC: 1421782.

Difference in the induction of macrophage interleukin-1 production between viable and killed cells of Listeria monocytogenes.

Mitsuyama M, Igarashi K, Kawamura I, Ohmori T, Nomoto K Infect Immun. 1990; 58(5):1254-60.

PMID: 2108928 PMC: 258617. DOI: 10.1128/iai.58.5.1254-1260.1990.

Dissociated development of T cells mediating delayed-type hypersensitivity and protective T cells against Listeria monocytogenes and their functional difference in lymphokine production.

Tsukada H, Kawamura I, Arakawa M, Nomoto K, Mitsuyama M Infect Immun. 1991; 59(10):3589-95.

PMID: 1910007 PMC: 258925. DOI: 10.1128/iai.59.10.3589-3595.1991.

A dissociated induction of MCF-producing and MAF-producing T cells specific for Listeria monocytogenes in the in vitro primary culture system.

Muramori K, Mitsuyama M, Handa T, Serushago B, Nomoto K Immunology. 1991; 72(3):373-9.

PMID: 1902819 PMC: 1384398.

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