Oligosaccharide-based Quality Evaluation of Atractylodis Rhizome and a Strategy for Simplifying Its Quality Control

Overview

Journal BMC Chem

Publisher Springer Nature

Specialty Chemistry

Date 2019 Aug 7

PMID 31384839

Citations 2

Authors

Dan Zhuang

Jing Qin

Hui-Yang Wang

Yi Zhang

Chun-Yao Liu

Qing-Qing Ding

Guang-Ping Lv

Affiliations

Soon will be listed here.

Abstract

Background: Atractylodis rhizoma, is the dried rhizomes of (Thunb.) DC. or (DC.) Koidz. Both of two are pharmacologically and economically important, while with differences in efficacy. Therefore, an authentication system is vital for evaluation the quality and discrimination adulteration of Atractylodis rhizoma. Fructooligosaccharides (FOS), which are regarded as functional ingredients in Atractylodis rhizoma, have not been used for quality control of Atractylodis rhizoma for shortage of reference compounds.

Results: A HPLC-ELSD method was developed for the quantification of FOS in Atractylodis rhizoma. And chemometrics analysis showed that 2 markers including content of degree of polymerization (DP) 12 and total content of DP 3-15 could be used as the main distinctive elements for quality evaluation of Atractylodis rhizome. Actually, the separation and purification of high DP FOS, such as DP 12, is still a challenge because of high polarity. Then DP 5-based qualification evaluation was investigated for quality control of Atractylodis rhizoma. The results showed that and could be clearly separated.

Conclusions: DP 5-based quantification method was credible and effectively adopted for solving the shortage of reference compounds and improving the quality control of Atractylodis rhizoma.

Citing Articles

A Comparison Study on Polysaccharides Extracted from (DC.) Koidz. Using Different Methods: Structural Characterization and Anti-SGC-7901 Effect of Combination with Apatinib.

Zhou P, Xiao W, Wang X, Wu Y, Zhao R, Wang Y Molecules. 2022; 27(15).

PMID: 35897903 PMC: 9332031. DOI: 10.3390/molecules27154727.

Atractylodis Rhizoma: A review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control.

Zhang W, Zhao Z, Chang L, Cao Y, Wang S, Kang C J Ethnopharmacol. 2020; 266:113415.

PMID: 32987126 PMC: 7521906. DOI: 10.1016/j.jep.2020.113415.

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