Mycobacterial Mannose-capped Lipoarabinomannan: a Modulator Bridging Innate and Adaptive Immunity

Overview

Journal Emerg Microbes Infect

Specialty Infectious Diseases

Date 2019 Aug 6

PMID 31379262

Citations 21

Authors

Kai-Liang Zhou

Xin Li

Xiao-Lian Zhang

Qin Pan

Affiliations

Soon will be listed here.

Abstract

Mannose-capped lipoarabinomannan (ManLAM) is a high molecular mass amphipathic lipoglycan identified in pathogenic () and Bacillus Calmette-Guérin (BCG). ManLAM, serves as both an immunogen and a modulator of the host immune system, and its critical role in mycobacterial survival during infection has been well-characterized. ManLAM can be recognized by various types of receptors on both innate and adaptive immune cells, including macrophages, dendritic cells (DCs), neutrophils, natural killer T (NKT) cells, T cells and B cells. MamLAM has been shown to affect phagocytosis, cytokine production, antigen presentation, T cell activation and polarization, as well as antibody production. Exploring the mechanisms underlying the roles of ManLAM during mycobacterial infection will aid in improving tuberculosis (TB) prevention, diagnosis and treatment interventions. In this review, we highlight the interaction between ManLAM and receptors, intracellular signalling pathways triggered by ManLAM and its roles in both innate and adaptive immune responses.

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