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Thoracic Manifestations of Rheumatoid Arthritis

Overview
Journal Clin Chest Med
Specialty Pulmonary Medicine
Date 2019 Aug 5
PMID 31376890
Citations 29
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Abstract

Rheumatoid arthritis (RA) is commonly associated with pulmonary disease that can affect any anatomic compartment of the thorax. The most common intrathoracic manifestations of RA include interstitial lung disease, airway disease, pleural disease, rheumatoid nodules, and drug-induced toxicity. Patients with RA with thoracic involvement often present with nonspecific respiratory symptoms, although many are asymptomatic. Therefore, clinicians should routinely consider pulmonary disease when evaluating any patient with RA, particularly one with known risk factors. The optimal screening, diagnostic, and treatment strategies for RA-associated pulmonary disease remain uncertain and are the focus of ongoing investigation.

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References
1.
Caplan A . Certain unusual radiological appearances in the chest of coal-miners suffering from rheumatoid arthritis. Thorax. 1953; 8(1):29-37. PMC: 1019224. DOI: 10.1136/thx.8.1.29. View

2.
Hakala M, TIILIKAINEN A, Hameenkorpi R, Ilonen J, Jalava S, Ruuska P . Rheumatoid arthritis with pleural effusion includes a subgroup with autoimmune features and HLA-B8, Dw3 association. Scand J Rheumatol. 1986; 15(3):290-6. DOI: 10.3109/03009748609092595. View

3.
Toussirot E, Berthelot J, Pertuiset E, Bouvard B, Gaudin P, Wendling D . Pulmonary nodulosis and aseptic granulomatous lung disease occurring in patients with rheumatoid arthritis receiving tumor necrosis factor-alpha-blocking agent: a case series. J Rheumatol. 2009; 36(11):2421-7. DOI: 10.3899/jrheum.090030. View

4.
Dawson J, Fewins H, Desmond J, Lynch M, Graham D . Fibrosing alveolitis in patients with rheumatoid arthritis as assessed by high resolution computed tomography, chest radiography, and pulmonary function tests. Thorax. 2001; 56(8):622-7. PMC: 1746113. DOI: 10.1136/thorax.56.8.622. View

5.
Inchingolo R, Varone F, Sgalla G, Richeldi L . Existing and emerging biomarkers for disease progression in idiopathic pulmonary fibrosis. Expert Rev Respir Med. 2018; 13(1):39-51. DOI: 10.1080/17476348.2019.1553620. View