Renin-angiotensin-system, a Potential Pharmacological Candidate, in Acute Respiratory Distress Syndrome During Mechanical Ventilation

Overview

Journal Pulm Pharmacol Ther

Specialty Pulmonary Medicine

Date 2019 Aug 4

PMID 31376462

Citations 41

Authors

Di Wang

Xiao-Qing Chai

Costan G Magnussen

Graeme R Zosky

Shu-Hua Shu

Xin Wei

Shan-Shan Hu

Affiliations

Soon will be listed here.

Abstract

While effective treatments for acute respiratory distress syndrome (ARDS) are lacking, mechanical lung ventilation can sustain adequate gas exchange in critically ill patients with respiratory failure due to ARDS. However, as a result of the phenomenon of ventilator-induced lung injury (VILI), there is an increasing need to seek beneficial pharmacological therapies for ARDS. Recent studies have suggested the renin-angiotensin system (RAS), which consists of the ACE/Ang-II/AT1R axis and ACE2/Ang-(1-7)/MasR axis, plays a dual role in the pathogenesis of ARDS and VILI. This review highlights the deleterious action of ACE/Ang-II/AT1R axis and the beneficial role of ACE2/Ang-(1-7)/MasR axis, as well as AT2R, in VILI and ARDS, and also discusses the possibility of targeting RAS components with pharmacological interventions to improve outcomes in ARDS.

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