Precision Medicine for Obstructive Sleep Apnea

Overview

Journal Sleep Med Clin

Publisher Elsevier

Specialty Psychiatry

Date 2019 Aug 4

PMID 31375207

Citations 13

Authors

Matthew Light

Robert L Owens

Christopher N Schmickl

Atul Malhotra

Affiliations

Soon will be listed here.

Abstract

Increasingly, obstructive sleep apnea treatment is being recognized as amenable to a precision medicine approach. Many pathophysiologic mechanisms (endotypes) beyond anatomic compromise have now been identified and are readily determined during polysomnography, although randomized controlled trials of endotype-specific therapies are needed. Research indicates that endotypes may also be important in predicting both adherence to therapy and disease consequences (phenotypes). Biomarker discovery and Big Data approaches derived from wearable technology are areas of active investigation and may allow more robust conclusions to be drawn over time, such that patients may soon fully realize the benefits from fresh insights into sleep science.

Citing Articles

[Respiratory Disease in the Era of Big Data].

Prats L, Luis Izquierdo J Open Respir Arch. 2024; 2(4):284-288.

PMID: 38620700 PMC: 7481841. DOI: 10.1016/j.opresp.2020.07.003.

The role of upper airway and facial skeleton anatomy in the evolution of obstructive sleep apnea: an 8-year follow-up.

Nicolau A, Figueiredo D, Stefanini R, de Aguiar Vidigal T, Bittencourt L, Andersen M Sleep Breath. 2023; 28(1):401-409.

PMID: 37682494 DOI: 10.1007/s11325-023-02907-z.

Role of precision medicine in obstructive sleep apnoea.

Liu Y, Abdul Ghafoor A, Hajipour M, Ayas N BMJ Med. 2023; 2(1):e000218.

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Computed Tomography and Cephalometric Evaluation of Obstructive Sleep Apnea Syndrome.

Mahale A, Rao P, Ullal S, Fernandes M, Prabhu S Indian J Otolaryngol Head Neck Surg. 2023; 74(Suppl 3):5134-5143.

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Planetary sleep medicine: Studying sleep at the individual, population, and planetary level.

Bragazzi N, Garbarino S, Puce L, Trompetto C, Marinelli L, Curra A Front Public Health. 2022; 10:1005100.

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