Recent Trends in Enhancing the Resistance of Cultivated Plants to Heavy Metal Stress by Transgenesis and Transcriptional Programming

Overview

Journal Mol Biotechnol

Publisher Springer

Specialties Biotechnology
Molecular Biology

Date 2019 Aug 3

PMID 31372919

Citations 2

Authors

Elena S Belykh

Tatiana A Maystrenko

Ilya O Velegzhaninov

Affiliations

Soon will be listed here.

Abstract

Normal growth and development of high plants strongly depends on the concentration of microelements, including essential heavy metals, in the substrate. However, an excess of those elements may become harmful. Therefore, micronutrient concentrations in plant tissue should be well-balanced and controlled by homeostatic mechanisms. The advancement of knowledge on the regulation of metal homeostasis in plants is important for phytoremediation of metal-contaminated soil and for micronutrient malnutrition control. Experimental data from loss-of-function and gain-of-function studies, including functional descriptions and classifications have presented new opportunities for multiplex CRISPR/dCas9-driven control of gene expression and have opened up new prospects for the goal-seeking regulation of metal homeostasis in plants. The aim of this review is to help for multiplex transcriptional programming targets search by summarizing and analyzing data on possible ways to handle a plant's ability to maintain metal homeostasis.

Citing Articles

The Potential of CRISPR/Cas Technology to Enhance Crop Performance on Adverse Soil Conditions.

Gajardo H, Gomez-Espinoza O, Boscariol Ferreira P, Carrer H, Bravo L Plants (Basel). 2023; 12(9).

PMID: 37176948 PMC: 10181257. DOI: 10.3390/plants12091892.

Genome-wide identification and function analysis of HMAD gene family in cotton (Gossypium spp.).

Wang Q, Lu X, Chen X, Zhao L, Han M, Wang S BMC Plant Biol. 2021; 21(1):386.

PMID: 34416873 PMC: 8377987. DOI: 10.1186/s12870-021-03170-8.

References

Guerinot M . The ZIP family of metal transporters. Biochim Biophys Acta. 2000; 1465(1-2):190-8. DOI: 10.1016/s0005-2736(00)00138-3. View

Thomine S, Wang R, Ward J, Crawford N, Schroeder J . Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes. Proc Natl Acad Sci U S A. 2000; 97(9):4991-6. PMC: 18345. DOI: 10.1073/pnas.97.9.4991. View

Vert G, Briat J, Curie C . Arabidopsis IRT2 gene encodes a root-periphery iron transporter. Plant J. 2001; 26(2):181-9. DOI: 10.1046/j.1365-313x.2001.01018.x. View

Thomine S, Lelievre F, Debarbieux E, Schroeder J, Barbier-Brygoo H . AtNRAMP3, a multispecific vacuolar metal transporter involved in plant responses to iron deficiency. Plant J. 2003; 34(5):685-95. DOI: 10.1046/j.1365-313x.2003.01760.x. View

Sancenon V, Puig S, Mateu-Andres I, Dorcey E, Thiele D, Penarrubia L . The Arabidopsis copper transporter COPT1 functions in root elongation and pollen development. J Biol Chem. 2004; 279(15):15348-55. DOI: 10.1074/jbc.M313321200. View

Williams L, Mills R . P(1B)-ATPases--an ancient family of transition metal pumps with diverse functions in plants. Trends Plant Sci. 2005; 10(10):491-502. DOI: 10.1016/j.tplants.2005.08.008. View

Lanquar V, Lelievre F, Bolte S, Hames C, Alcon C, Neumann D . Mobilization of vacuolar iron by AtNRAMP3 and AtNRAMP4 is essential for seed germination on low iron. EMBO J. 2005; 24(23):4041-51. PMC: 1356305. DOI: 10.1038/sj.emboj.7600864. View

Hou X, Tong H, Selby J, Dewitt J, Peng X, He Z . Involvement of a cell wall-associated kinase, WAKL4, in Arabidopsis mineral responses. Plant Physiol. 2005; 139(4):1704-16. PMC: 1310553. DOI: 10.1104/pp.105.066910. View

Andres-Colas N, Sancenon V, Rodriguez-Navarro S, Mayo S, Thiele D, Ecker J . The Arabidopsis heavy metal P-type ATPase HMA5 interacts with metallochaperones and functions in copper detoxification of roots. Plant J. 2005; 45(2):225-36. DOI: 10.1111/j.1365-313X.2005.02601.x. View

10.

Schaaf G, Honsbein A, Meda A, Kirchner S, Wipf D, von Wiren N . AtIREG2 encodes a tonoplast transport protein involved in iron-dependent nickel detoxification in Arabidopsis thaliana roots. J Biol Chem. 2006; 281(35):25532-40. DOI: 10.1074/jbc.M601062200. View

11.

Korenkov V, Hirschi K, Crutchfield J, Wagner G . Enhancing tonoplast Cd/H antiport activity increases Cd, Zn, and Mn tolerance, and impacts root/shoot Cd partitioning in Nicotiana tabacum L. Planta. 2007; 226(6):1379-87. DOI: 10.1007/s00425-007-0577-0. View

12.

Hanikenne M, Talke I, Haydon M, Lanz C, Nolte A, Motte P . Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4. Nature. 2008; 453(7193):391-5. DOI: 10.1038/nature06877. View

13.

Wojas S, Clemens S, Hennig J, Sklodowska A, Kopera E, Schat H . Overexpression of phytochelatin synthase in tobacco: distinctive effects of AtPCS1 and CePCS genes on plant response to cadmium. J Exp Bot. 2008; 59(8):2205-19. PMC: 2413269. DOI: 10.1093/jxb/ern092. View

14.

Wong C, Cobbett C . HMA P-type ATPases are the major mechanism for root-to-shoot Cd translocation in Arabidopsis thaliana. New Phytol. 2008; 181(1):71-78. DOI: 10.1111/j.1469-8137.2008.02638.x. View

15.

Segond D, Dellagi A, Lanquar V, Rigault M, Patrit O, Thomine S . NRAMP genes function in Arabidopsis thaliana resistance to Erwinia chrysanthemi infection. Plant J. 2009; 58(2):195-207. DOI: 10.1111/j.1365-313X.2008.03775.x. View

16.

Lin Y, Liang H, Yang S, Boch A, Clemens S, Chen C . Arabidopsis IRT3 is a zinc-regulated and plasma membrane localized zinc/iron transporter. New Phytol. 2009; 182(2):392-404. DOI: 10.1111/j.1469-8137.2009.02766.x. View

17.

Burkhead J, Gogolin Reynolds K, Abdel-Ghany S, Cohu C, Pilon M . Copper homeostasis. New Phytol. 2009; 182(4):799-816. DOI: 10.1111/j.1469-8137.2009.02846.x. View

18.

Wojas S, Hennig J, Plaza S, Geisler M, Siemianowski O, Sklodowska A . Ectopic expression of Arabidopsis ABC transporter MRP7 modifies cadmium root-to-shoot transport and accumulation. Environ Pollut. 2009; 157(10):2781-9. DOI: 10.1016/j.envpol.2009.04.024. View

19.

Lanquar V, Schnell Ramos M, Lelievre F, Barbier-Brygoo H, Krieger-Liszkay A, Kramer U . Export of vacuolar manganese by AtNRAMP3 and AtNRAMP4 is required for optimal photosynthesis and growth under manganese deficiency. Plant Physiol. 2010; 152(4):1986-99. PMC: 2850043. DOI: 10.1104/pp.109.150946. View

20.

Siemianowski O, Mills R, Williams L, Antosiewicz D . Expression of the P(₁B) -type ATPase AtHMA4 in tobacco modifies Zn and Cd root to shoot partitioning and metal tolerance. Plant Biotechnol J. 2010; 9(1):64-74. DOI: 10.1111/j.1467-7652.2010.00531.x. View