Progressive Study of Effects of Erianin on Anticancer Activity

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2019 Aug 3

PMID 31371985

Citations 22

Authors

Yuying Zhang

Qianqian Zhang

Fanhua Wei

Na Liu

Affiliations

Soon will be listed here.

Abstract

Erianin is the major bisbenzyl compound extracted from the traditional Chinese medicine Lindl. Erianin possesses many biological properties relevant to cancer prevention and therapy. The previous studies confirmed that antitumor effects of erianin are regulated with multiple signaling pathways. The mechanisms of erianin are numerous, and most of them induce cancer cell apoptosis that may be intrinsic or extrinsic and modulate the ROS/JNK signaling pathways. Invasion, migration, and angiogenesis represent emerging targets of erianin and support its anticancer properties. This review aimed to summarize the recent advances in the antitumor activity of erianin and to provide a rationale for further exploring the potential application of erianin in overcoming cancer in the future.

Citing Articles

Erianin inhibits the progression of DDP-resistant lung adenocarcinoma by regulating the Wnt/β-catenin pathway and activating the caspase-3 for apoptosis in vitro and in vivo.

Tang L, Ruan Y, Wang B, Zhang M, Xue J, Wang T Hereditas. 2024; 161(1):48.

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Integrated metabolomic and transcriptomic analyses of and reveal the biosynthetic pathway from gigantol to erianin.

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Research progress on the regulatory and pharmacological mechanism of chemical components of Dendrobium.

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Potential Action Mechanism of Erianin in Relieving MNNG-triggered Chronic Atrophic Gastritis.

Jiang Q, Fan G, Wu K Cell Biochem Biophys. 2024; 83(1):1035-1044.

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Discovery of the Natural Bibenzyl Compound Erianin in Dendrobium Inhibiting the Growth and EMT of Gastric Cancer through Downregulating the LKB1-SIK2/3-PARD3 Pathway.

Wei X, Liu Q, Liu L, Wang D, Liu J, Zhu Q Int J Mol Sci. 2024; 25(14).

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