Medullasin Induces Activated Killer Cells from Human Lymphocytes

Overview

Journal Jpn J Cancer Res

Specialty Oncology

Date 1988 Jun 1

PMID 3137194

Citations 2

Authors

Y Aoki

Affiliations

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Abstract

Treatment of human lymphocytes with a physiological amount of medullasin, a serine protease found in bone marrow cells, resulted in the induction of activated killer cells which can lyse both natural killer-sensitive and -resistant target cells. The optimum concentration of medullasin was 20 micrograms/ml when lymphocytes were treated with the protease at 37 degrees C for 60 min. Kinetic studies of the induction revealed that the maximum induction was achieved 24 hr after medullasin treatment.

Citing Articles

Azurocidin induces elastinolytic activity of medullasin.

Aoki Y Proc Jpn Acad Ser B Phys Biol Sci. 2015; 82(7):251-6.

PMID: 25792788 PMC: 4343063. DOI: 10.2183/pjab.82.251.

Induction of activated killer cells from human lymphocytes by medullasin (a serine protease in bone marrow cells).

Aoki Y, Hase T, Oshimi K, Suzuki K Immunology. 1992; 75(3):481-7.

PMID: 1572695 PMC: 1384743.

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