Effect of Ambient Air Quality on Exacerbation of COPD in Patients and Its Potential Mechanism

Overview

Journal Int J Chron Obstruct Pulmon Dis

Publisher Dove Medical Press

Specialty Pulmonary Medicine

Date 2019 Aug 3

PMID 31371937

Citations 6

Authors

Peng Yan

Pengfei Liu

Rong Lin

Kun Xiao

Sheling Xie

Kaifei Wang

Yuhan Zhang

Xanxue He

Shifeng Zhao

Xingang Zhang

Martin Liu

Lixin Xie

Affiliations

Soon will be listed here.

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a disease of continuous progress and environmental factors may affect the progress. COPD patients' activity tolerance and quality of life are associated with air quality. COPD exacerbation from the perspective of geographical air quality has not been reported.

Objectives: To explore environmental effect of two different geographical places on COPD exacerbation and the effect of cigarette smoke extract and carbon particles on bronchial epithelial cell viability.

Methods: Total 139 COPD patients, who lived in Beijing during summer and temporarily migrated to Sanya city in winter, have been enrolled. Respiratory symptoms and lung function data were collected when they were living in Beijing or Sanya, respectively. Effect of cigarette smoke extract plus ultrafine carbon particles on airway epithelial cells were studied.

Measurements And Main Results: Air pollution as measured by air quality index (AQI) in Beijing summer (113.1±14.2) was significantly worse than that in Sanya winter (49.4±8.9, <0.001). The COPD Assessment Test (CAT) score was significantly higher in Beijing (26.4±7.1) than that in Sanya (20.0±8.0, =0.019). Modified Medical Research Council dyspnea scale was also significantly higher in Beijing (2.9±0.9) than that in Sanya (1.9±0.8, <0.001). FEV was significantly improved when the patients were in Sanya (48.88±24.78%) compared to that in Beijing (41.79±20.06%, <0.01). Compared with Beijing and Sanya, the relative risk (RR) of hospitalization and acute exacerbation were 1.64 and 3.36, respectively. In vitro study demonstrated that apoptosis of BEAS2B cells in response to cigarette smoke extract plus ultrafine carbon particles (25.50±2.10%) was significantly higher than that of control culture (2.30±1.05%, <0.01).

Conclusion: These findings suggested that ambient air pollution cause COPD exacerbation, and that air pollutants particle matters induce apoptosis of airway epithelial cells.

Citing Articles

Genetic Variants in the Adhesive G Protein-Coupled Receptor ADGRG6 are Associated with Increased Susceptibility to COPD in the Elderly Han Chinese Population of Southern China.

Chen F, Zhao J, Mo R, Ding X, Zhang Y, Huang L Int J Chron Obstruct Pulmon Dis. 2024; 19:2599-2610.

PMID: 39650745 PMC: 11624663. DOI: 10.2147/COPD.S478095.

Exploring the Relationship Between Education, Living Environment, and Anxiety/Depression Among Stable Patients: Insights from the COPD-AD China Registry Study.

Wu D, Long B, Huang B, Zhong X, Chen X, Shen X Int J Chron Obstruct Pulmon Dis. 2024; 19:2063-2071.

PMID: 39346627 PMC: 11430393. DOI: 10.2147/COPD.S455923.

Effects of climate and environment on migratory old people with allergic diseases in China: Protocol for a Sanya cohort study.

Hu Q, Shi X, Wang D, Huang Y, Gao J, Guan H Heliyon. 2023; 9(11):e21949.

PMID: 38045199 PMC: 10692782. DOI: 10.1016/j.heliyon.2023.e21949.

The Effects and Pathogenesis of PM2.5 and Its Components on Chronic Obstructive Pulmonary Disease.

Wang Q, Liu S Int J Chron Obstruct Pulmon Dis. 2023; 18:493-506.

PMID: 37056681 PMC: 10086390. DOI: 10.2147/COPD.S402122.

Prediction of COPD acute exacerbation in response to air pollution using exosomal circRNA profile and Machine learning.

Meng Q, Wang J, Cui J, Li B, Wu S, Yun J Environ Int. 2022; 168:107469.

PMID: 36041244 PMC: 9939562. DOI: 10.1016/j.envint.2022.107469.

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