The Role of Visfatin Levels in Gingival Crevicular Fluid As a Potential Biomarker in the Relationship Between Obesity and Periodontal Disease

Overview

Journal J Appl Oral Sci

Specialty Dentistry

Date 2019 Aug 1

PMID 31365708

Citations 13

Authors

Deniz Cetiner

Ahu Uraz

Seniha Oztoprak

Gulcin Akca

Affiliations

Soon will be listed here.

Abstract

Objectives: Visfatin is an adipokine that plays an important role in immune functions as a growth factor, enzyme, and pro-inflammatory mediator. We aimed to determine the levels of visfatin, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF) in both obese/non-obese patients, with/without generalized chronic periodontitis (GCP).

Methodology: Patients were categorized as obese (O) (n=31) or non-obese (nO) (n=19). Groups were divided into four subgroups according to periodontal conditions: (1) periodontally healthy without obesity (nO-Ctrl); (2) GCP without obesity (nO-CP); (3) periodontally healthy with obesity (O-Ctrl); and (4) GCP with obesity (O-CP). Demographic variables, anthropometric and laboratory data were recorded. Periodontal parameters were measured at baseline and 3rd months after either non-surgical periodontal treatment or calorie -restricted diet therapy. At the same time, GCF samples were taken from patients to analyze TNF-alpha, IL-6,and visfatin levels.

Results: Periodontal parameters were significantly higher in the O group than in the nO group (P<0.05). IL-6 levels were higher in the O group than in the nO group (P<0.001). The visfatin levels of the obese patients were reduceddecreased following the treatments (P<0.05). Cholesterol levels were higher in the O group than in the nO groups (P<0.05). IL-6 levels were higher in O-CP and O-Ctrl groups than in the nO-Ctrl group (P<0.05). Compared to the other groups, visfatin levels were significantly higher in the O-CP group but decreased following treatment (P<0.05).

Conclusions: Our findings suggest that visfatin and IL-6 levels in GCF are associated with the pathogenesis of obesity and periodontitis. Within the limits of this study, we considered that there might be an association between the lipid profile and periodontitis on systemically healthy individuals.

Citing Articles

Comparison of visfatin levels before and after non-surgical periodontal therapy: A systematic review and meta-analysis.

Tajik Z, Mehrafarid H, Bayani M, Almasi-Hashiani A PLoS One. 2025; 20(2):e0315035.

PMID: 39970162 PMC: 11838901. DOI: 10.1371/journal.pone.0315035.

The Potential of Gingival Crevicular Fluid as a Tool for Molecular Diagnosis: A Systematic Review.

Cuevas-Gonzalez M, Cuevas-Gonzalez J, Espinosa-Cristobal L, Tovar-Carrillo K, Saucedo-Acuna R, Garcia-Calderon A Biomed Res Int. 2024; 2024:5560866.

PMID: 39445210 PMC: 11496582. DOI: 10.1155/2024/5560866.

Systemic benefits of periodontal therapy in patients with obesity and periodontitis: a systematic review.

Menezes C, Barbirato D, Fogacci M, Maranon-Vasquez G, Carneiro J, Maia L Braz Oral Res. 2024; 38:e031.

PMID: 38597549 PMC: 11376685. DOI: 10.1590/1807-3107bor-2024.vol38.0031.

Association between visfatin and periodontitis: a systematic review and meta-analysis.

Li Y, Xin C, Xie J, Sun X PeerJ. 2024; 12:e17187.

PMID: 38560458 PMC: 10981885. DOI: 10.7717/peerj.17187.

Salivary and gingival crevicular fluid biomarkers of periodontal health and/or obesity among children and adolescents: A systematic review and meta-analysis.

Deng Q, Wong H, Peng S Heliyon. 2024; 10(1):e23782.

PMID: 38226238 PMC: 10788453. DOI: 10.1016/j.heliyon.2023.e23782.

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