Clinical Value of Interferon-γ Release Assay in the Diagnosis of Active Tuberculosis

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2019 Aug 1

PMID 31363369

Citations 7

Authors

Lu Ai

Pinning Feng

Dubo Chen

Shaoqian Chen

Hongxu Xu

Affiliations

Soon will be listed here.

Abstract

Sensitivity and specificity of the interferon-γ release test for active tuberculosis screening were evaluated. Due to the high-test cost of imported IGRAs, QFT-GIT and T-SPOT.TB, we applied a cheaper domestic TB-IGRA which was approved in China recently. We recruited 740 patients and performed tuberculosis interferon release test (IGRAs), detection of IgG antibody (TB-IgG) and tuberculin skin test (TST). The sensitivity of the three methods are 90.8, 40.0 and 75.45%, with specificity of 76.62, 74.47 and 72.27%. The area under the ROC curve according to the value of T-N detected by IGRAs was 0.878 (95% CI, 0.839-0.917), with the area under the curve for the diagnosis of active pulmonary tuberculosis and extrapulmonary tuberculosis being 0.839 and 0.841 respectively. The interferon-γ release test seems to be superior to TST and TB-IgG as a screening tool for the detection of active tuberculosis in China.

Citing Articles

Combining interferon-γ release assays and metagenomic next-generation sequencing for diagnosis of pulmonary tuberculosis: a retrospective study.

Liu Y, Fang M, Yuan C, Yang Y, Yu L, Li Y BMC Infect Dis. 2024; 24(1):1316.

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Navigating Diagnostic Pitfalls: False Positivity in GeneXpert Mycobacterium Tuberculosis/Rifampicin Assay.

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Pulmonary tuberculosis associated acute fibrinous and organizing pneumonia: A case report and literature review.

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Diagnostic Efficacy of T-SPOT.TB for Active Tuberculosis in Adult: A Retrospective Study.

Sun Y, Yao X, Ni Y, Peng Y, Shi G Infect Drug Resist. 2022; 15:7077-7093.

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Screening of Long Non-coding RNAs Biomarkers for the Diagnosis of Tuberculosis and Preliminary Construction of a Clinical Diagnosis Model.

Chen J, Wu L, Lv Y, Liu T, Guo W, Song J Front Microbiol. 2022; 13:774663.

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