Blood Flow Deficits and Cerebrovascular Changes in a Dietary Model of Hyperhomocysteinemia

Overview

Journal ASN Neuro

Specialties Chemistry
Neurology

Date 2019 Aug 1

PMID 31362539

Citations 15

Authors

David J Braun

Erin Abner

Vikas Bakshi

Danielle S Goulding

Elizabeth M Grau

Ai-Ling Lin

Christopher M Norris

Tiffany L Sudduth

Scott J Webster

Donna M Wilcock

Linda J Van Eldik

Affiliations

Soon will be listed here.

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References

Sassi S, Cosmi B, Palareti G, Legnani C, Grossi G, Musolesi S . Influence of age, sex and vitamin status on fasting and post-methionine load plasma homocysteine levels. Haematologica. 2002; 87(9):957-64. View

Thai S, Iruela-Arispe M . Expression of ADAMTS1 during murine development. Mech Dev. 2002; 115(1-2):181-5. DOI: 10.1016/s0925-4773(02)00115-6. View

Clarke R, Bennett D, Parish S, Lewington S, Skeaff M, Eussen S . Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals. Am J Clin Nutr. 2014; 100(2):657-66. PMC: 4095663. DOI: 10.3945/ajcn.113.076349. View

Michel T, Vanhoutte P . Cellular signaling and NO production. Pflugers Arch. 2010; 459(6):807-16. PMC: 3774002. DOI: 10.1007/s00424-009-0765-9. View

Ford A, Almeida O . Effect of homocysteine lowering treatment on cognitive function: a systematic review and meta-analysis of randomized controlled trials. J Alzheimers Dis. 2012; 29(1):133-49. DOI: 10.3233/JAD-2012-111739. View

Sudduth T, Weekman E, Price B, Gooch J, Woolums A, Norris C . Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID). Neuroscience. 2016; 341:42-51. PMC: 5911565. DOI: 10.1016/j.neuroscience.2016.11.024. View

Janson J, Galarza C, Murua A, Quintana I, Przygoda P, Waisman G . Prevalence of hyperhomocysteinemia in an elderly population. Am J Hypertens. 2002; 15(5):394-7. DOI: 10.1016/s0895-7061(01)02165-3. View

Hudak M, Koehler R, Rosenberg A, Traystman R, Jones Jr M . Effect of hematocrit on cerebral blood flow. Am J Physiol. 1986; 251(1 Pt 2):H63-70. DOI: 10.1152/ajpheart.1986.251.1.H63. View

Ernest S, Hosack A, OBrien W, Rosenblatt D, Nadeau J . Homocysteine levels in A/J and C57BL/6J mice: genetic, diet, gender, and parental effects. Physiol Genomics. 2005; 21(3):404-10. DOI: 10.1152/physiolgenomics.00199.2004. View

10.

Salles-Montaudon N, Parrot F, Balas D, Bouzigon E, Rainfray M, Emeriau J . Prevalence and mechanisms of hyperhomocysteinemia in elderly hospitalized patients. J Nutr Health Aging. 2003; 7(2):111-6. View

11.

Novakovic R, Geelen A, Ristic-Medic D, Nikolic M, Souverein O, McNulty H . Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly. Ann Nutr Metab. 2018; 73(1):30-43. DOI: 10.1159/000490003. View

12.

Troen A, Shea-Budgell M, Shukitt-Hale B, Smith D, Selhub J, Rosenberg I . B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proc Natl Acad Sci U S A. 2008; 105(34):12474-9. PMC: 2517600. DOI: 10.1073/pnas.0805350105. View

13.

Smith A, Refsum H, Bottiglieri T, Fenech M, Hooshmand B, McCaddon A . Homocysteine and Dementia: An International Consensus Statement. J Alzheimers Dis. 2018; 62(2):561-570. PMC: 5836397. DOI: 10.3233/JAD-171042. View

14.

Zhang F, Slungaard A, Vercellotti G, Iadecola C . Superoxide-dependent cerebrovascular effects of homocysteine. Am J Physiol. 1998; 274(6):R1704-11. DOI: 10.1152/ajpregu.1998.274.6.R1704. View

15.

Zimmermann K, Opitz N, Dedio J, Renne C, Muller-Esterl W, Oess S . NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 2002; 99(26):17167-72. PMC: 139423. DOI: 10.1073/pnas.252345399. View

16.

Price B, Wilcock D, Weekman E . Hyperhomocysteinemia as a Risk Factor for Vascular Contributions to Cognitive Impairment and Dementia. Front Aging Neurosci. 2018; 10:350. PMC: 6220027. DOI: 10.3389/fnagi.2018.00350. View

17.

Oller J, Mendez-Barbero N, Josue Ruiz E, Villahoz S, Renard M, Canelas L . Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome. Nat Med. 2017; 23(2):200-212. DOI: 10.1038/nm.4266. View

18.

Selhub J . Homocysteine metabolism. Annu Rev Nutr. 1999; 19:217-46. DOI: 10.1146/annurev.nutr.19.1.217. View

19.

Esse R, Barroso M, Tavares de Almeida I, Castro R . The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art. Int J Mol Sci. 2019; 20(4). PMC: 6412520. DOI: 10.3390/ijms20040867. View

20.

Gottschall P, Howell M . ADAMTS expression and function in central nervous system injury and disorders. Matrix Biol. 2015; 44-46:70-6. PMC: 5068130. DOI: 10.1016/j.matbio.2015.01.014. View