Spatiotemporally Controlled Nano-sized Third Harmonic Generation Agents

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2019 Jul 31

PMID 31360600

Citations 5

Authors

Dmitry Nevozhay

Michael Weiger

Peter Friedl

Konstantin V Sokolov

Affiliations

Soon will be listed here.

Abstract

Here, we present a new class of third harmonic generation (THG) imaging probes that can be activated with precise spatiotemporal control using non-linear excitation. These probes consist of lipid-coated perfluorocarbon nanodroplets with embedded visible chromophores. The droplets undergo phase transition from liquid to gas upon heating mediated by two-photon absorption of NIR light by the embedded dyes. Resulting microbubbles provide a sharp, local refractive index mismatch, which makes an excellent source of THG signal. Potential applications of these probes include activatable THG agents for biological imaging and "on-demand" delivery of various compounds under THG monitoring.

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References

Walsh A, Cook R, Lee J, Arteaga C, Skala M . Collagen density and alignment in responsive and resistant trastuzumab-treated breast cancer xenografts. J Biomed Opt. 2015; 20(2):26004. PMC: 4335617. DOI: 10.1117/1.JBO.20.2.026004. View

Ahrens E, Helfer B, OHanlon C, Schirda C . Clinical cell therapy imaging using a perfluorocarbon tracer and fluorine-19 MRI. Magn Reson Med. 2014; 72(6):1696-701. PMC: 4253123. DOI: 10.1002/mrm.25454. View

Bestvater F, Spiess E, Stobrawa G, Hacker M, Feurer T, Porwol T . Two-photon fluorescence absorption and emission spectra of dyes relevant for cell imaging. J Microsc. 2002; 208(Pt 2):108-15. DOI: 10.1046/j.1365-2818.2002.01074.x. View

Hammerich L, Bhardwaj N, Kohrt H, Brody J . In situ vaccination for the treatment of cancer. Immunotherapy. 2016; 8(3):315-30. DOI: 10.2217/imt.15.120. View

Wolf K, Alexander S, Schacht V, Coussens L, von Andrian U, van Rheenen J . Collagen-based cell migration models in vitro and in vivo. Semin Cell Dev Biol. 2009; 20(8):931-41. PMC: 4021709. DOI: 10.1016/j.semcdb.2009.08.005. View

Fernandes D, Kolios M . Intrinsically absorbing photoacoustic and ultrasound contrast agents for cancer therapy and imaging. Nanotechnology. 2018; 29(50):505103. DOI: 10.1088/1361-6528/aadfbc. View

Sletten E, Swager T . Fluorofluorophores: fluorescent fluorous chemical tools spanning the visible spectrum. J Am Chem Soc. 2014; 136(39):13574-7. PMC: 4577963. DOI: 10.1021/ja507848f. View

Dubreil L, Leroux I, Ledevin M, Schleder C, Lagalice L, Lovo C . Multi-harmonic Imaging in the Second Near-Infrared Window of Nanoparticle-Labeled Stem Cells as a Monitoring Tool in Tissue Depth. ACS Nano. 2017; 11(7):6672-6681. DOI: 10.1021/acsnano.7b00773. View

Rueden C, Schindelin J, Hiner M, DeZonia B, Walter A, Arena E . ImageJ2: ImageJ for the next generation of scientific image data. BMC Bioinformatics. 2017; 18(1):529. PMC: 5708080. DOI: 10.1186/s12859-017-1934-z. View

10.

Zhu D, Larin K, Luo Q, Tuchin V . Recent progress in tissue optical clearing. Laser Photon Rev. 2013; 7(5):732-757. PMC: 3856422. DOI: 10.1002/lpor.201200056. View

11.

Dietzel S, Hermann S, Kugel Y, Sellner S, Uhl B, Hirn S . Multiphoton Microscopy of Nonfluorescent Nanoparticles In Vitro and In Vivo. Small. 2016; 12(24):3245-57. DOI: 10.1002/smll.201503766. View

12.

Rapoport N, Efros A, Christensen D, Kennedy A, Nam K . Microbubble Generation in Phase-Shift Nanoemulsions used as Anticancer Drug Carriers. Bubble Sci Eng Technol. 2010; 1(1-2):31-39. PMC: 2777721. DOI: 10.1179/175889709X446516. View

13.

Tuchin V, Maksimova I, Zimnyakov D, Kon I, Mavlyutov A, Mishin A . Light propagation in tissues with controlled optical properties. J Biomed Opt. 2012; 2(4):401-17. DOI: 10.1117/12.281502. View

14.

Weigelin B, Bakker G, Friedl P . Third harmonic generation microscopy of cells and tissue organization. J Cell Sci. 2016; 129(2):245-55. DOI: 10.1242/jcs.152272. View

15.

Gao Z, Kennedy A, Christensen D, Rapoport N . Drug-loaded nano/microbubbles for combining ultrasonography and targeted chemotherapy. Ultrasonics. 2007; 48(4):260-70. PMC: 2637393. DOI: 10.1016/j.ultras.2007.11.002. View

16.

Cui L, Tokarz D, Cisek R, Ng K, Wang F, Chen J . Organized Aggregation of Porphyrins in Lipid Bilayers for Third Harmonic Generation Microscopy. Angew Chem Int Ed Engl. 2015; 54(47):13928-32. DOI: 10.1002/anie.201506171. View

17.

Sarder P, Yazdanfar S, Akers W, Tang R, Sudlow G, Egbulefu C . All-near-infrared multiphoton microscopy interrogates intact tissues at deeper imaging depths than conventional single- and two-photon near-infrared excitation microscopes. J Biomed Opt. 2013; 18(10):106012. PMC: 3805921. DOI: 10.1117/1.JBO.18.10.106012. View

18.

Kripfgans O, Fowlkes J, Miller D, Eldevik O, Carson P . Acoustic droplet vaporization for therapeutic and diagnostic applications. Ultrasound Med Biol. 2000; 26(7):1177-89. DOI: 10.1016/s0301-5629(00)00262-3. View

19.

Sheeran P, Wong V, Luois S, McFarland R, Ross W, Feingold S . Decafluorobutane as a phase-change contrast agent for low-energy extravascular ultrasonic imaging. Ultrasound Med Biol. 2011; 37(9):1518-30. PMC: 4450864. DOI: 10.1016/j.ultrasmedbio.2011.05.021. View

20.

Dietzel S, Pircher J, Nekolla A, Gull M, Brandli A, Pohl U . Label-free determination of hemodynamic parameters in the microcirculaton with third harmonic generation microscopy. PLoS One. 2014; 9(6):e99615. PMC: 4059650. DOI: 10.1371/journal.pone.0099615. View