Treatment Implications of Natural Compounds Targeting Lipid Metabolism in Nonalcoholic Fatty Liver Disease, Obesity and Cancer

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2019 Jul 31

PMID 31360108

Citations 18

Authors

Can Cheng

Songming Zhuo

Bo Zhang

Xu Zhao

Ying Liu

Chaoliang Liao

Jing Quan

Zhenzhen Li

Ann M Bode

Ya Cao

Xiangjian Luo

Affiliations

Soon will be listed here.

Abstract

Metabolic disorders can lead to a scarcity or excess of certain metabolites such as glucose, lipids, proteins, purines, and metal ions, which provide the biochemical foundation and directly contribute to the etiology of metabolic diseases. Nonalcoholic fatty liver disease, obesity, and cancer are common metabolic disorders closely associated with abnormal lipid metabolism. In this review, we first describe the regulatory machinery of lipid metabolism and its deregulation in metabolic diseases. Next, we enumerate and integrate the mechanism of action of some natural compounds, including terpenoids and flavonoids, to ameliorate the development of metabolic diseases by targeting lipid metabolism. Medicinal natural products have an established history of use in health care and therapy. Natural compounds might provide a good source of potential therapeutic agents for treating or preventing metabolic diseases with lipid metabolic abnormalities.

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