Ion Effects on the Conformation and Dynamics of Repetitive Domains of a Spider Silk Protein: Implications for Solubility and β-sheet Formation

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2019 Jul 30

PMID 31355386

Citations 13

Authors

Nur Alia Oktaviani

Akimasa Matsugami

Fumiaki Hayashi

Keiji Numata

Affiliations

Soon will be listed here.

Abstract

The effect of ions on the structure and dynamics of a spider silk protein is elucidated. Chaotropic ions prevent intra- and inter-molecular interactions on the repetitive domain, which are required to maintain the solubility, while kosmotropic ions promote hydrogen bond interactions in the glycine-rich region, which are a prerequisite for β-sheet formation.

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