Phenotypic Expression of Autoimmunity in Children With Autoimmune Thyroid Disorders

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2019 Jul 30

PMID 31354636

Citations 16

Authors

Tommaso Aversa

Domenico Corica

Giuseppina Zirilli

Giovanni Battista Pajno

Giuseppina Salzano

Filippo De Luca

Malgorzata Wasniewska

Affiliations

Soon will be listed here.

Abstract

Autoimmune thyroid diseases (AITDs), including Hashimoto's thyroiditis (HT) and Graves' disease (GD), tend to aggregate with other non-thyroidal autoimmune diseases (NTADs). Aim of this Mini-review is to report the most recent insights concerning the clustering of NTADs in pediatric patients with either HT or GD, the pathophysiology of AITDs and the metamorphic thyroid autoimmunity. A systematic literature research of the last 15 years, according to EQUATOR statement, was carried out through MEDLINE via PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) Embase, CINAHL, Cochrane Library, based on the following keywords: (autoimmune thyroid disease OR Hashimoto thyroiditis OR Grave's disease) AND (autoimmune comorbidities OR extra-thyroidal autoimmune disorders) AND (children OR adolescents OR pediatrics) AND (celiac disease OR type 1 diabetes mellitus OR arthropathies OR cutaneous diseases) AND (Turner syndrome OR Down syndrome). One-hundred and twenty-eight manuscripts were extrapolated but only seventeen were eligible. On the basis of the available reports it may be inferred that clustering of NTADs can be significantly modified by both patients' age at AITDs presentation and association with Down's syndrome (DS). Particularly, the association of AITDs with celiac disease and type 1 diabetes was most commonly reported in children than in adults. A sequential shifting from HT to GD has been described in children with AITDs, and it seems to be more frequent in children with DS than in those without DS. Coexistence of autoimmune diseases might be the result of a complex interaction among genetics, environment and epigenetic modifications that are able to affect gene expression, immune system response and, finally, the pathogenesis of autoimmune diseases.

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References

Vaidya B, Kendall-Taylor P, Pearce S . The genetics of autoimmune thyroid disease. J Clin Endocrinol Metab. 2002; 87(12):5385-97. DOI: 10.1210/jc.2002-020492. View

Einarsdottir E, Soderstrom I, Lofgren-Burstrom A, Haraldsson S, Nilsson-Ardnor S, Penha-Goncalves C . The CTLA4 region as a general autoimmunity factor: an extended pedigree provides evidence for synergy with the HLA locus in the etiology of type 1 diabetes mellitus, Hashimoto's thyroiditis and Graves' disease. Eur J Hum Genet. 2003; 11(1):81-4. DOI: 10.1038/sj.ejhg.5200903. View

Ueda H, Howson J, Esposito L, Heward J, Snook H, Chamberlain G . Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature. 2003; 423(6939):506-11. DOI: 10.1038/nature01621. View

Ikegami H, Awata T, Kawasaki E, Kobayashi T, Maruyama T, Nakanishi K . The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan. J Clin Endocrinol Metab. 2005; 91(3):1087-92. DOI: 10.1210/jc.2005-1407. View

Aust G, Krohn K, Morgenthaler N, Schroder S, Schutz A, Edelmann J . Graves' disease and Hashimoto's thyroiditis in monozygotic twins: case study as well as transcriptomic and immunohistological analysis of thyroid tissues. Eur J Endocrinol. 2005; 154(1):13-20. DOI: 10.1530/eje.1.02063. View

Kinik S, Ozcay F, Varan B . Type I diabetes mellitus, Hashimoto's thyroiditis and celiac disease in an adolescent with Down syndrome. Pediatr Int. 2006; 48(4):433-5. DOI: 10.1111/j.1442-200X.2006.02238.x. View

McLachlan S, Nagayama Y, Pichurin P, Mizutori Y, Chen C, Misharin A . The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells. Endocrinology. 2007; 148(12):5724-33. DOI: 10.1210/en.2007-1024. View

Cosnes J, Cellier C, Viola S, Colombel J, Michaud L, Sarles J . Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free diet. Clin Gastroenterol Hepatol. 2008; 6(7):753-8. DOI: 10.1016/j.cgh.2007.12.022. View

Elfstrom P, Montgomery S, Kampe O, Ekbom A, Ludvigsson J . Risk of thyroid disease in individuals with celiac disease. J Clin Endocrinol Metab. 2008; 93(10):3915-21. DOI: 10.1210/jc.2008-0798. View

10.

Lammer C, Weimann E . Early onset of type I diabetes mellitus, Hashimoto's thyroiditis and celiac disease in a 7-yr-old boy with Down's syndrome. Pediatr Diabetes. 2008; 9(4 Pt 2):423-5. DOI: 10.1111/j.1399-5448.2008.00355.x. View

11.

Ludgate M, Emerson C . Metamorphic thyroid autoimmunity. Thyroid. 2008; 18(10):1035-7. DOI: 10.1089/thy.2008.1551. View

12.

Salzano G, Lombardo F, Arrigo T, Sferlazzas C, Wasniewska M, Valenzise M . Association of five autoimmune diseases in a young woman with Down's syndrome. J Endocrinol Invest. 2009; 33(3):202-3. DOI: 10.1007/BF03346582. View

13.

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

14.

Cooper G, Bynum M, Somers E . Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases. J Autoimmun. 2009; 33(3-4):197-207. PMC: 2783422. DOI: 10.1016/j.jaut.2009.09.008. View

15.

De Luca F, Corrias A, Salerno M, Wasniewska M, Gastaldi R, Cassio A . Peculiarities of Graves' disease in children and adolescents with Down's syndrome. Eur J Endocrinol. 2009; 162(3):591-5. DOI: 10.1530/EJE-09-0751. View

16.

Boelaert K, Newby P, Simmonds M, Holder R, Carr-Smith J, Heward J . Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. Am J Med. 2010; 123(2):183.e1-9. DOI: 10.1016/j.amjmed.2009.06.030. View

17.

Jorgensen K, Rostgaard K, Bache I, Biggar R, Nielsen N, Tommerup N . Autoimmune diseases in women with Turner's syndrome. Arthritis Rheum. 2010; 62(3):658-66. DOI: 10.1002/art.27270. View

18.

Wasniewska M, Corrias A, Arrigo T, Lombardo F, Salerno M, Mussa A . Frequency of Hashimoto's thyroiditis antecedents in the history of children and adolescents with graves' disease. Horm Res Paediatr. 2010; 73(6):473-6. DOI: 10.1159/000313395. View

19.

Latini G, Knipp G, Mantovani A, Marcovecchio M, Chiarelli F, Soder O . Endocrine disruptors and human health. Mini Rev Med Chem. 2010; 10(9):846-55. DOI: 10.2174/138955710791608271. View

20.

Knapp P . Risk of other autoimmune diseases increased in people with Graves' disease or Hashimoto's thyroiditis relative to the general UK population. Evid Based Med. 2010; 15(5):158-9. DOI: 10.1136/ebm1091. View