Bioprinting Approaches to Engineering Vascularized 3D Cardiac Tissues

Overview

Journal Curr Cardiol Rep

Publisher Current Science

Specialty Cardiology & Vascular Diseases

Date 2019 Jul 29

PMID 31352612

Citations 18

Authors

Nazan Puluca

Soah Lee

Stefanie Doppler

Andrea Munsterer

Martina Dressen

Markus Krane

Sean M Wu

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: 3D bioprinting technologies hold significant promise for the generation of engineered cardiac tissue and translational applications in medicine. To generate a clinically relevant sized tissue, the provisioning of a perfusable vascular network that provides nutrients to cells in the tissue is a major challenge. This review summarizes the recent vascularization strategies for engineering 3D cardiac tissues.

Recent Findings: Considerable steps towards the generation of macroscopic sizes for engineered cardiac tissue with efficient vascular networks have been made within the past few years. Achieving a compact tissue with enough cardiomyocytes to provide functionality remains a challenging task. Achieving perfusion in engineered constructs with media that contain oxygen and nutrients at a clinically relevant tissue sizes remains the next frontier in tissue engineering. The provisioning of a functional vasculature is necessary for maintaining a high cell viability and functionality in engineered cardiac tissues. Several recent studies have shown the ability to generate tissues up to a centimeter scale with a perfusable vascular network. Future challenges include improving cell density and tissue size. This requires the close collaboration of a multidisciplinary teams of investigators to overcome complex challenges in order to achieve success.

Citing Articles

3D-bioprinted cardiac tissues and their potential for disease modeling.

Restan Perez M, da Silva V, Cortez P, Joddar B, Willerth S J 3D Print Med. 2024; 7(2).

PMID: 38250545 PMC: 10798787. DOI: 10.2217/3dp-2022-0023.

Recent advances in soluble decellularized extracellular matrix for heart tissue engineering and organ modeling.

Kafili G, Kabir H, Jalali Kandeloos A, Golafshan E, Ghasemi S, Mashayekhan S J Biomater Appl. 2023; 38(5):577-604.

PMID: 38006224 PMC: 10676626. DOI: 10.1177/08853282231207216.

Three-Dimensional Bioprinting of Ovine Aortic Valve Endothelial and Interstitial Cells for the Development of Multicellular Tissue Engineered Tissue Constructs.

Immohr M, Teichert H, Dos Santos Adrego F, Schmidt V, Sugimura Y, Bauer S Bioengineering (Basel). 2023; 10(7).

PMID: 37508814 PMC: 10376021. DOI: 10.3390/bioengineering10070787.

Three-Dimensionally Printed Hydrogel Cardiac Patch for Infarct Regeneration Based on Natural Polysaccharides.

Loureiro J, Miguel S, Galvan-Chacon V, Patrocinio D, Blas Pagador J, Sanchez-Margallo F Polymers (Basel). 2023; 15(13).

PMID: 37447470 PMC: 10346776. DOI: 10.3390/polym15132824.

Bioprinting of Cardiac Tissue in Space: Where Are We?.

Tabury K, Rehnberg E, Baselet B, Baatout S, Moroni L Adv Healthc Mater. 2023; 12(23):e2203338.

PMID: 37312654 PMC: 11469151. DOI: 10.1002/adhm.202203338.

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