The Role of Cell Mediated Immunopathogenesis in Thyroid-associated Ophthalmopathy

Overview

Journal Int J Ophthalmol

Specialty Ophthalmology

Date 2019 Jul 26

PMID 31341815

Citations 3

Authors

Zhen-Mao Wang

Zheng-Yan Wang

Yan Lu

Affiliations

Soon will be listed here.

Abstract

Currently, thyroid-associated ophthalmopathy (TAO) lacks effective treatment due to our lack of clarity in its immunopathogenesis. Orbital fibroblasts play a key role in altering inflammation and immune response in TAO, and are considered as the key target and effector cells in its pathogenesis. The orbit infiltrating CD34+ fibrocytes add on to the process by expressing high levels of autoantigens and inflammatory cytokines, while also differentiating into myofibroblasts or adipocytes. This review focuses on the role of orbital fibroblasts and CD34+ fibrocytes in the pathogenesis of TAO, highlighting the basis of emerging treatments.

Citing Articles

Immunological Processes in the Orbit and Indications for Current and Potential Drug Targets.

Cieplinska K, Niedziela E, Kowalska A J Clin Med. 2024; 13(1).

PMID: 38202079 PMC: 10780108. DOI: 10.3390/jcm13010072.

Mechanisms of immune-related differentially expressed genes in thyroid-associated ophthalmopathy based on the GEO database.

Gao Y, Li W Ann Transl Med. 2022; 10(17):926.

PMID: 36172114 PMC: 9511181. DOI: 10.21037/atm-22-3470.

miR-96-5p Induces Orbital Fibroblasts Differentiation by Targeting Smad7 and Promotes the Development of Thyroid-Associated Ophthalmopathy.

Kang J, Li Y, Zou Y, Zhao Z, Jiao L, Zhang H Evid Based Complement Alternat Med. 2022; 2022:8550307.

PMID: 35265151 PMC: 8898793. DOI: 10.1155/2022/8550307.

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