Mitogenic Activity of Staphylococcal Peptidoglycan

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1979 Mar 1

PMID 313370

Citations 17

Authors

R Dziarski

A Dziarski

Affiliations

Soon will be listed here.

Abstract

Staphylococcus aureus peptidoglycan displayed a marked dose-dependent mitogenic activity for mouse splenocytes and human peripheral blood lymphocytes in vitro, as measured by increased [3H]thymidine incorporation. Similarly it was mitogenic for athymic nude mouse spleen cells, whereas no blastogenic effect was observed in T cell-enriched and B cell-depleted mouse lymphocyte cultures. These data demonstrate that peptidoglycan-responding cells in mouse spleen cell cultures are B lymphocytes.

Citing Articles

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Soluble peptidoglycan-induced monokine production can be blocked by anti-CD14 monoclonal antibodies and by lipid A partial structures.

Weidemann B, Brade H, Rietschel E, Dziarski R, Bazil V, Kusumoto S Infect Immun. 1994; 62(11):4709-15.

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Modulation of mitogenic responsiveness by staphylococcal peptidoglycan.

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Delayed hypersensitivity to Staphylococcus aureus in mice: characterization of a membrane immunogen involved in delayed hypersensitivity.

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