Diacetylcurcumin: Its Potential Antiarthritic Effect on a Freund's Complete Adjuvant-Induced Murine Model

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2019 Jul 24

PMID 31330908

Citations 3

Authors

Carolina Escobedo-Martinez

Silvia Laura Guzman-Gutierrez

Maria Isabel Carrillo-Lopez

Martha Alicia Deveze-Alvarez

Alfonso Trujillo-Valdivia

William Meza-Morales

Raul G Enriquez

Affiliations

Soon will be listed here.

Abstract

The present study aims to evaluate the antiarthritic activity of diacetylcurcumin (DAC), a synthetic derivative where the free phenolic groups of curcumin are derivatized by acetylation, thereby conferring greater lipophilicity to the parent molecule and partially overcoming the limited systemic bioavailability of curcumin. Antiarthritic activity was evaluated on a Freund's complete adjuvant (FCA)-induced murine model of arthritis. Oral administration of DAC (60 and 120 mg/kg) resulted in a significant inhibition of inflammation in the acute and chronic phases, respectively, demonstrating an improved and sustained anti-inflammatory effect, comparable to that of curcumin (150 mg/kg) in the chronic stage at a lower dose. Phenylbutazone (80 mg/kg) was used as a reference drug. The pharmacological consequence of DAC or curcumin treatment is the prevention of secondary lesions commonly associated with this biological model.

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