Extract Protects Against Reflux Esophagitis by Blocking H Histamine Receptors

Overview

Journal Prev Nutr Food Sci

Date 2019 Jul 23

PMID 31328120

Citations 2

Authors

Joo Yun Kim

Sung Sik Jang

Jung Lyoul Lee

Jae-Hun Sim

Jae-Jung Shim

Affiliations

Soon will be listed here.

Abstract

has been used in East Asia as a folk medicine for symptoms such as inflammation, allergy, and gastritis. Administration of extract to pylori-ligated rat stomachs reduces gastric acid secretion and alleviates esophagus damage caused by gastric reflux. Therefore, in this study we aimed to investigate whether extracts inhibit reflux esophagitis by blocking H histamine receptor (HR). Dimaprit, a HR specific agonist, induced intracellular cyclic adenosine monophosphate (cAMP) production in U937 cells. Pretreatment with extracts significantly blocked dimaprit-induced cAMP production in a concentration-dependent manner. To extracted with different ethanol concentrations to determine the optimum method. We found that the 70% ethanol extract showed the most potent HR antagonistic effect against dimaprit-induced cAMP production. However, water extract did not show any HR blocking effect. These findings suggest that extracted using ethanol specifically inhibits gastric acid secretion and reduces esophageal injury by blocking HR in a competitive manner. Therefore, extracts may be used in food or medicine to prevent HR-related diseases, such as gastric hyperacidity and reflux esophagitis.

Citing Articles

Efficacy and Safety of the Extract on Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Multicenter Study.

Shin J, Oh T, Kim J, Shim J, Lee J J Clin Med. 2021; 10(22).

PMID: 34830605 PMC: 8621513. DOI: 10.3390/jcm10225323.

Gastroprotective Effects of Leaf Extracts by Suppressing Gastric cAMP and Increasing Gastric Mucins.

Kim J, Park S, Nam W, Nam B, Bae C, Kim H Prev Nutr Food Sci. 2020; 25(2):158-165.

PMID: 32676467 PMC: 7333002. DOI: 10.3746/pnf.2020.25.2.158.

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