Inflammation and Vascular Ageing: From Telomeres to Novel Emerging Mechanisms

Overview

Journal High Blood Press Cardiovasc Prev

Specialty Cardiology & Vascular Diseases

Date 2019 Jul 21

PMID 31325087

Citations 9

Authors

Martina Chiriaco

Georgios Georgiopoulos

Emiliano Duranti

Luca Antonioli

Ilaria Puxeddu

Monica Nannipieri

Javier Rosada

Corrado Blandizzi

Stefano Taddei

Agostino Virdis

Stefano Masi

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease (CVD) remains the leading cause of morbility and mortality worldwide. The identification of common cardiovascular risk factors has led to the development of effective treatments that enabled a significant reduction of the global cardiovascular disease burden. However, a significant proportion of cardiovascular risk remains unexplained by these risk factors leaving many individuals at risk of cardiovascular events despite good control of the risk factors. Recent randomized clinical trials and Mendelian randomization studies have suggested that inflammation explains a significant proportion of the residual cardiovascular risk in subjects with good control of risk factors. An accelerated process of vascular ageing is increasingly recognized as a potential mechanism by which inflammation might increase the risk of CVD. In turn, cellular ageing represents an important source of inflammation within the vascular wall, potentially creating a vicious cycle that might promote progression of atherosclerosis, independently from the individual cardiovascular risk factor burden. In this review, we summarise current evidence suggesting a role for biological ageing in CVD and how inflammation might act as a key mediator of this association.

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