Cerebrospinal Fluid Dynamics in Pediatric Pseudotumor Cerebri Syndrome

Overview

Journal Childs Nerv Syst

Specialty Pediatrics

Date 2019 Jul 21

PMID 31325030

Citations 6

Authors

Afroditi-Despina Lalou

James S McTaggart

Zofia H Czosnyka

Matthew R Garnett

Deepa Krishnakumar

Marek Czosnyka

Affiliations

Soon will be listed here.

Abstract

Purpose: There is a growing body of evidence highlighting the importance of comprehensive intracranial pressure (ICP) values in pseudotumor cerebri syndrome (PTCS). Due to the highly dynamic nature of ICP, several methods of ICP monitoring have been established, including the CSF infusion study. We have performed a retrospective review of the CSF dynamics measurements for all pediatric patients investigated for PTCS in our center and examined their diagnostic value compared with clinical classification.

Methods: We retrospectively recruited 31 patients under 16 years of age investigated for PTCS by CSF infusion test. We used the clinically provided Friedman classification 13/31 patients with definite PTCS (group A), 13/31 with probable PTCS (group B), and 5/31 not PTCS (group C), to compare CSF dynamics in the 3 groups.

Results: CSF pressure (CSFp) was significantly increased in group A (29.18 ± 7.72 mmHg) compared with B (15.31 ± 3.47 mmHg; p = 1.644e-05) and C (17.51 ± 5.87; p = 0.01368). The amplitude (AMP) was higher in the definite (2.18 ± 2.06 mmHg) than in group B (0.68 ± 0.37; p = 0.01382). There was no in either CSFp or AMP between groups B and C. No lower breakpoint of the AMP-P line was observed in group A but was present in 2/13 and 2/5 patients in groups B and C. In group A, sagittal sinus pressure (SSp) and elasticity were the only parameters above threshold (p = 4.2e-06 and p = 0.001953, respectively), In group B, only the elasticity was significantly higher than the threshold (p = 004257). Group C did not have any of the parameters raised. The AUC of CSFp, elasticity, and SSp for the 3 groups was 93.8% (84.8-100% CI).

Conclusions: Monitoring of CSFp and its dynamics, besides providing a more precise methodology for measuring CSFp, could yield information on the dynamic parameters of CSFp that cannot be derived from CSFp as a number, accurately differentiating between the clinically and radiologically derived entities of PTCS.

Citing Articles

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Observational study of intracranial pressure instability in patients with pseudotumour cerebri syndrome.

Lalou A, Czosnyka Z, Czosnyka M Brain Spine. 2024; 4:102758.

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Clinical and prognostic importance of craniospinal elastance and pressure volume index in pediatric pseudotumor cerebri syndrome.

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Is Lumbar Puncture Needed? - Noninvasive Assessment of ICP Facilitates Decision Making in Patients with Suspected Idiopathic Intracranial Hypertension.

Schmidt B, Czosnyka M, Cardim D, Czosnyka Z, Rosengarten B Ultraschall Med. 2021; 44(2):e91-e98.

PMID: 34496407 PMC: 10063336. DOI: 10.1055/a-1586-6487.

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