Drug Delivery Systems for Vitamin D Supplementation and Therapy

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2019 Jul 21

PMID 31323777

Citations 18

Authors

Eliza Glowka

Joanna Stasiak

Janina Lulek

Affiliations

Soon will be listed here.

Abstract

Vitamin D (VD) is a fat-soluble prohormone well known for its role in regulating calcium and phosphate metabolism. It has been clinically used for many years to prevent rickets in children, osteomalacia, and osteoporosis in adults. VD insufficiency is a common medical condition, and many supplements are available in the market in order to increase serum 25-hydroxy VD levels to recommended amounts. Over the course of the last decades, it has become increasingly clear that calcitriol, an active form of VD, regulates multiple cellular processes with effects on normal and malignant cell growth and differentiation, and on the immune and cardiovascular function. Increasing evidence supports the role of the VD system in cancer prevention and therapy. Due to many pleiotropic and beneficial effects in extra-skeletal disorders, VD has gained potential and become an interesting active for encapsulation into drug delivery systems. The purpose of this review is to present the diversity of drug delivery systems that have been reported for VD or VD derivatives in an orderly manner across the following categories: Oral administration, application on the skin, cancer prevention/therapy, and other diseases or routes of administration.

Citing Articles

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References

Hansen C, Hamberg K, Binderup E, Binderup L . Seocalcitol (EB 1089): a vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation. Curr Pharm Des. 2000; 6(7):803-28. DOI: 10.2174/1381612003400371. View

Korbel J, Sebok B, Kerenyi M, Mahrle G . Enhancement of the antiparakeratotic potency of calcitriol and tacalcitol in liposomal preparations in the mouse tail test. Skin Pharmacol Appl Skin Physiol. 2001; 14(5):291-5. DOI: 10.1159/000056359. View

Cavalier E, Delanaye P, Chapelle J, Souberbielle J . Vitamin D: current status and perspectives. Clin Chem Lab Med. 2008; 47(2):120-7. DOI: 10.1515/CCLM.2009.036. View

Yamagishi N, Namioka T, Okura N, Sato S, Kim D, Furuhama K . Application of a reservoir-type calcitriol transdermal patch in dairy cattle. J Vet Med Sci. 2009; 71(6):845-8. DOI: 10.1292/jvms.71.845. View

Grossmann R, Tangpricha V . Evaluation of vehicle substances on vitamin D bioavailability: a systematic review. Mol Nutr Food Res. 2010; 54(8):1055-61. PMC: 3033429. DOI: 10.1002/mnfr.200900578. View

Coelho I, Andrade L, Saldanha L, Trovao Diniz E, Griz L, Bandeira F . Bioavailability of vitamin D3 in non-oily capsules: the role of formulated compounds and implications for intermittent replacement. Arq Bras Endocrinol Metabol. 2010; 54(2):239-43. DOI: 10.1590/s0004-27302010000200022. View

Li Q, Liu C, Huang Z, Xue F . Preparation and characterization of nanoparticles based on hydrophobic alginate derivative as carriers for sustained release of vitamin D3. J Agric Food Chem. 2011; 59(5):1962-7. DOI: 10.1021/jf1020347. View

Knudsen N, Jorgensen L, Hansen J, Vermehren C, Frokjaer S, Foged C . Targeting of liposome-associated calcipotriol to the skin: effect of liposomal membrane fluidity and skin barrier integrity. Int J Pharm. 2011; 416(2):478-85. DOI: 10.1016/j.ijpharm.2011.03.014. View

Sun F, Ju C, Chen J, Liu S, Liu N, Wang K . Nanoparticles based on hydrophobic alginate derivative as nutraceutical delivery vehicle: vitamin D3 loading. Artif Cells Blood Substit Immobil Biotechnol. 2011; 40(1-2):113-9. DOI: 10.3109/10731199.2011.597759. View

10.

Dobnig H . A review of the health consequences of the vitamin D deficiency pandemic. J Neurol Sci. 2011; 311(1-2):15-8. DOI: 10.1016/j.jns.2011.08.046. View

11.

Goff J, Koszewski N, Haynes J, Horst R . Targeted delivery of vitamin D to the colon using β-glucuronides of vitamin D: therapeutic effects in a murine model of inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2011; 302(4):G460-9. PMC: 5142426. DOI: 10.1152/ajpgi.00156.2011. View

12.

Luo Y, Teng Z, Wang Q . Development of zein nanoparticles coated with carboxymethyl chitosan for encapsulation and controlled release of vitamin D3. J Agric Food Chem. 2012; 60(3):836-43. DOI: 10.1021/jf204194z. View

13.

Wimalawansa S . Vitamin D in the new millennium. Curr Osteoporos Rep. 2012; 10(1):4-15. DOI: 10.1007/s11914-011-0094-8. View

14.

Patel M, San Martin-Gonzalez M . Characterization of ergocalciferol loaded solid lipid nanoparticles. J Food Sci. 2012; 77(1):N8-13. DOI: 10.1111/j.1750-3841.2011.02517.x. View

15.

Knudsen N, Ronholt S, Salte R, Jorgensen L, Thormann T, Basse L . Calcipotriol delivery into the skin with PEGylated liposomes. Eur J Pharm Biopharm. 2012; 81(3):532-9. DOI: 10.1016/j.ejpb.2012.04.005. View

16.

Haham M, Ish-Shalom S, Nodelman M, Duek I, Segal E, Kustanovich M . Stability and bioavailability of vitamin D nanoencapsulated in casein micelles. Food Funct. 2012; 3(7):737-44. DOI: 10.1039/c2fo10249h. View

17.

Ziani K, Fang Y, McClements D . Encapsulation of functional lipophilic components in surfactant-based colloidal delivery systems: vitamin E, vitamin D, and lemon oil. Food Chem. 2012; 134(2):1106-12. DOI: 10.1016/j.foodchem.2012.03.027. View

18.

Almouazen E, Bourgeois S, Jordheim L, Fessi H, Briancon S . Nano-encapsulation of vitamin D3 active metabolites for application in chemotherapy: formulation study and in vitro evaluation. Pharm Res. 2012; 30(4):1137-46. DOI: 10.1007/s11095-012-0949-4. View

19.

Crommelin D, Florence A . Towards more effective advanced drug delivery systems. Int J Pharm. 2013; 454(1):496-511. DOI: 10.1016/j.ijpharm.2013.02.020. View

20.

Li H, Wang Q, Xiao Y, Bao C, Li W . 25-Hydroxyvitamin D(3)-loaded PLA microspheres: in vitro characterization and application in diabetic periodontitis models. AAPS PharmSciTech. 2013; 14(2):880-9. PMC: 3666022. DOI: 10.1208/s12249-013-9978-5. View