Epidemiology, Pathogenesis, and Diagnosis of Addison's Disease in Adults

Overview

Journal J Endocrinol Invest

Publisher Springer

Specialty Endocrinology

Date 2019 Jul 20

PMID 31321757

Citations 33

Authors

C Betterle

F Presotto

J Furmaniak

Affiliations

Soon will be listed here.

Abstract

Background: Addison's disease (AD) is a rare disorder and among adult population in developed countries is most commonly caused by autoimmunity. In contrast, in children genetic causes are responsible for AD in the majority of patients.

Purpose: This review describes epidemiology, pathogenesis, genetics, natural history, clinical manifestations, immunological markers and diagnostic strategies in patients with AD. Standard care treatments including the management of patients during pregnancy and adrenal crises consistent with the recent consensus statement of the European Consortium and the Endocrine Society Clinical Practice Guideline are described. In addition, emerging therapies designed to improve the quality of life and new strategies to modify the natural history of autoimmune AD are discussed.

Conclusions: Progress in optimizing replacement therapy for patients with AD has allowed the patients to lead a normal life. However, continuous education of patients and health care professionals of ever-present danger of adrenal crisis is essential to save lives of patients with AD.

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