Genetic and Environmental Contributors for Celiac Disease

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2019 Jul 20

PMID 31321608

Citations 12

Authors

Gloria Serena

Rosiane Lima

Alessio Fasano

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Celiac disease (CD) is an autoimmune enteropathy triggered by gluten. The purpose of this review is to examine the major genetic and environmental factors that contribute to CD pathogenesis.

Recent Findings: We reviewed the current state of knowledge on the genetic and environmental components that play a role in CD onset. A genome-wide association study (GWAS) analysis has highlighted several genes other than HLA involved in CD. Recent studies have shown that HLA haplotype influences the microbiome composition in infants and that dysbiosis in the intestinal microflora, in turn, contributes to loss of tolerance to gluten. Recently, observational studies have discussed the hypothesis stating that breast-feeding had a protective role against CD onset. CD etiology is influenced by genetic and environmental factors. A better understanding of these components would deepen our knowledge on the mechanisms that lead to loss of tolerance and could help in developing a more "personalized medicine."

Citing Articles

Celiac disease gut microbiome studies in the third millennium: reviewing the findings and gaps of available literature.

Luz V, Pereira S Front Med Technol. 2024; 6:1413637.

PMID: 39355139 PMC: 11444026. DOI: 10.3389/fmedt.2024.1413637.

Association of and Gene Polymorphism with Celiac Disease in Subjects from Punjab, Pakistan.

Zulfiqar S, Fiaz A, Khan W, Hussain M, Ali A, Ahmed N Genes (Basel). 2024; 15(7).

PMID: 39062631 PMC: 11275600. DOI: 10.3390/genes15070852.

Celiac disease: Pathogenesis, disease management and new insights into the herbal-based treatments.

Mittal P, Arora D, Parashar S, Goyal R, Khan A, Chopra H Narra J. 2024; 3(2):e147.

PMID: 38454981 PMC: 10919711. DOI: 10.52225/narra.v3i2.147.

Intestinal mRNA expression analysis of polarity-related genes identified the discriminatory ability of CRB3 as a diagnostic marker for celiac disease.

Taraz T, Asri N, Nazemalhosseini-Mojarad E, Forouzesh F, Rezaei-Tavirani M, Rostami-Nejad M Immun Inflamm Dis. 2024; 12(2):e1186.

PMID: 38353316 PMC: 10865414. DOI: 10.1002/iid3.1186.

Baseline Fecal Microbiota in Pediatric Patients With Celiac Disease Is Similar to Controls But Dissimilar After 1 Year on the Gluten-Free Diet.

Sample D, Fouhse J, King S, Huynh H, Dieleman L, Willing B JPGN Rep. 2023; 2(4):e127.

PMID: 37206457 PMC: 10191547. DOI: 10.1097/PG9.0000000000000127.

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