Overview of Monogenic or Mendelian Forms of Hypertension

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2019 Jul 18

PMID 31312622

Citations 18

Authors

Rupesh Raina

Vinod Krishnappa

Abhijit Das

Harshesh Amin

Yeshwanter Radhakrishnan

Nikhil R Nair

Kirsten Kusumi

Affiliations

Soon will be listed here.

Abstract

Monogenic or Mendelian forms of hypertension are described as a group of conditions characterized by insults to the normal regulation of blood pressure by the kidney and adrenal gland. These alterations stem from single mutations that lead to maladaptive overabsorption of electrolytes with fluid shift into the vasculature, and consequent hypertension. Knowledge of these various conditions is essential in diagnosing pediatric or early-onset adult hypertension as they directly affect treatment strategies. Precise diagnosis with specific treatment regimens aimed at the underlying physiologic derangement can restore normotension and prevent the severe sequelae of chronic hypertension.

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