Comparative Analysis of Myocardial Protection with HTK Solution and Hypothermic Hyperkalemic Blood Solution in the Correction of Acyanogenic Congenital Cardiopathies - A Randomized Study

Overview

Journal Braz J Cardiovasc Surg

Specialty Cardiology & Vascular Diseases

Date 2019 Jul 17

PMID 31310464

Citations 1

Authors

Acrisio Sales Valente

Gustavo Porto Lustosa

Lia Alves Martins Mota

Adriano Lima

Fernando Antonio de Mesquita

Aloisio Gondim

Fabio Alercio Rodrigues

Ronald Guedes Pompeu

Klebia Castelo Branco

Affiliations

Soon will be listed here.

Abstract

Objective: The goal of the present study was to compare the myocardial protection obtained with histidine-tryptophan-ketoglutarate (HTK) cardioplegic solution (Custodiol®) and with intermittent hypothermic blood solution.

Methods: Two homogenous groups of 25 children with acyanotic congenital heart disease who underwent total correction with mean aortic clamping time of 60 minutes were evaluated in this randomized study. Troponin and creatine kinase-MB curves, vasoactive-inotropic score, and left ventricular function were obtained by echocardiogram in each group. The values were correlated and presented through graphs and tables after adequate statistical treatment.

Results: It was observed that values of all the studied variables varied over time, but there was no difference between the groups.

Conclusion: We conclude that in patients with acyanotic congenital cardiopathies submitted to total surgical correction, mean aortic clamping time around one hour, and cardiopulmonary bypass with moderate hypothermia, the HTK crystalloid cardioplegic solution offers the same myocardial protection as the cold-blood hyperkalemic cardioplegic solution analyzed, according to the variables considered in our study model.

Citing Articles

Theoretical and Practical Aspects in the Use of Bretschneider Cardioplegia.

Ghiragosian C, Harpa M, Stoica A, Sanziana F, Balau R, Al Hussein H J Cardiovasc Dev Dis. 2022; 9(6).

PMID: 35735807 PMC: 9225441. DOI: 10.3390/jcdd9060178.

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