HLA Class II-Restricted CD8+ T Cells in HIV-1 Virus Controllers

Overview

Journal Sci Rep

Specialty Science

Date 2019 Jul 17

PMID 31308388

Citations 5

Authors

Tinashe E Nyanhete

Alyse L Frisbee

Todd Bradley

William J Faison

Elizabeth Robins

Tamika Payne

Stephanie A Freel

Sheetal Sawant

Kent J Weinhold

Kevin Wiehe

Barton F Haynes

Guido Ferrari

Qi-Jing Li

M Anthony Moody

Georgia D Tomaras

Affiliations

Soon will be listed here.

Abstract

A paradigm shifting study demonstrated that induction of MHC class E and II-restricted CD8+ T cells was associated with the clearance of SIV infection in rhesus macaques. Another recent study highlighted the presence of HIV-1-specific class II-restricted CD8+ T cells in HIV-1 patients who naturally control infection (virus controllers; VCs). However, questions regarding class II-restricted CD8+ T cells ontogeny, distribution across different HIV-1 disease states and their role in viral control remain unclear. In this study, we investigated the distribution and anti-viral properties of HLA-DRB1*0701 and DQB1*0501 class II-restricted CD8+ T cells in different HIV-1 patient cohorts; and whether class II-restricted CD8+ T cells represent a unique T cell subset. We show that memory class II-restricted CD8+ T cell responses were more often detectable in VCs than in chronically infected patients, but not in healthy seronegative donors. We also demonstrate that VC CD8+ T cells inhibit virus replication in both a class I- and class II-dependent manner, and that in two VC patients the class II-restricted CD8+ T cells with an anti-viral gene signature expressed both CD4+ and CD8+ T cell lineage-specific genes. These data demonstrated that anti-viral memory class II-restricted CD8+ T cells with hybrid CD4+ and CD8+ features are present during natural HIV-1 infection.

Citing Articles

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