Platelets and Platelet-Derived Extracellular Vesicles in Liver Physiology and Disease

Overview

Journal Hepatol Commun

Specialty Gastroenterology

Date 2019 Jul 16

PMID 31304449

Citations 19

Authors

Alexandre Balaphas

Jeremy Meyer

Karin Sadoul

Pierre Fontana

Philippe Morel

Carmen Gonelle-Gispert

Leo H Buhler

Affiliations

Soon will be listed here.

Abstract

Beyond their role in hemostasis, platelets are proposed as key mediators of several physiological and pathophysiological processes of the liver, such as liver regeneration, toxic or viral acute liver injury, liver fibrosis, and carcinogenesis. The effects of platelets on the liver involve interactions with sinusoidal endothelial cells and the release of platelet-contained molecules following platelet activation. Platelets are the major source of circulating extracellular vesicles, which are suggested to play key roles in platelet interactions with endothelial cells in several clinical disorders. In the present review, we discuss the implications of platelet-derived extracellular vesicles in physiological and pathophysiological processes of the liver.

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