A Transplantable Cell Line Derived from Spontaneous Hepatocellular Carcinoma of the Hereditary Hepatitis LEC Rat

Overview

Journal Jpn J Cancer Res

Specialty Oncology

Date 1988 Feb 1

PMID 3130360

Citations 3

Authors

R Masuda

M C Yoshida

M Sasaki

K Dempo

M Mori

Affiliations

Soon will be listed here.

Abstract

A serially transplantable rat hepatocellular carcinoma (HCC) line was established. The primary spontaneous HCC which developed in a 506-day-old male hereditary hepatitis LEC rat was inoculated into young LEC rats. Only this HCC of 18 primary HCCs was successful in serial transplantation. The established cell line was histologically identical to the primary HCC showing a well-differentiated type with a trabecular structure of tumorous hepatocytes. The characteristic of albumin production was maintained. Chromosome analysis revealed rather widely dispersed polyploid chromosome numbers with a modal value at 96. Every metaphase contained two to five unusually large marker chromosomes.

Citing Articles

Gene expression of placental glutathione S-transferase in hereditary hepatitis and spontaneous hepatocarcinogenesis of LEC strain rats.

Masuda R, Yoshida M, Sasaki M Jpn J Cancer Res. 1989; 80(11):1024-7.

PMID: 2481661 PMC: 5917899. DOI: 10.1111/j.1349-7006.1989.tb02253.x.

High susceptibility to hepatocellular carcinoma development in LEC rats with hereditary hepatitis.

Masuda R, Yoshida M, Sasaki M, Dempo K, Mori M Jpn J Cancer Res. 1988; 79(7):828-35.

PMID: 2459092 PMC: 5917590. DOI: 10.1111/j.1349-7006.1988.tb00044.x.

Two-dimensional electrophoretic analysis of hepatitis-associated polypeptides in liver of LEC rats developing spontaneous hepatitis.

Wirth P, Fujimoto Y, Takahashi H, Mori M, Yoshida M, Sugimura T Jpn J Cancer Res. 1990; 81(5):477-82.

PMID: 2116396 PMC: 5918070. DOI: 10.1111/j.1349-7006.1990.tb02594.x.

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