Nature and Regulation of Protein Folding on the Ribosome

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 2019 Jul 15

PMID 31301980

Citations 61

Authors

Christopher A Waudby

Christopher M Dobson

John Christodoulou

Affiliations

Soon will be listed here.

Abstract

Co-translational protein folding is an essential process by which cells ensure the safe and efficient production and assembly of new proteins in their functional native states following biosynthesis on the ribosome. In this review, we describe recent progress in probing the changes during protein synthesis of the free energy landscapes that underlie co-translational folding and discuss the critical coupling between these landscapes and the rate of translation that ultimately determines the success or otherwise of the folding process. Recent developments have revealed a variety of mechanisms by which both folding and translation can be modulated or regulated, and we discuss how these effects are utilised by the cell to optimise the outcome of protein biosynthesis.

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