Whole-Cell Models and Simulations in Molecular Detail

Overview

Journal Annu Rev Cell Dev Biol

Publisher Annual Reviews

Specialty Cell Biology

Date 2019 Jul 13

PMID 31299173

Citations 25

Authors

Michael Feig

Yuji Sugita

Affiliations

Soon will be listed here.

Abstract

Comprehensive data about the composition and structure of cellular components have enabled the construction of quantitative whole-cell models. While kinetic network-type models have been established, it is also becoming possible to build physical, molecular-level models of cellular environments. This review outlines challenges in constructing and simulating such models and discusses near- and long-term opportunities for developing physical whole-cell models that can connect molecular structure with biological function.

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