The Structural Biology of the Dynamin-related Proteins: New Insights into a Diverse, Multitalented Family

Overview

Journal Traffic

Publisher Wiley

Specialties Biology
Physiology

Date 2019 Jul 13

PMID 31298797

Citations 20

Authors

Marijn G J Ford

Joshua S Chappie

Affiliations

Soon will be listed here.

Abstract

Dynamin-related proteins are multidomain, mechanochemical GTPases that self-assemble and orchestrate a wide array of cellular processes. Over the past decade, structural insights from X-ray crystallography and cryo-electron microscopy have reshaped our mechanistic understanding of these proteins. Here, we provide a historical perspective on these advances that highlights the structural attributes of different dynamin family members and explores how these characteristics affect GTP hydrolysis, conformational coupling and oligomerization. We also discuss a number of lingering challenges remaining in the field that suggest future directions of study.

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